Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 236-293-9 | CAS number: 13283-01-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2017.07.14 to 2017-09-29
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Version / remarks:
- 13. Apr. 2004
- Qualifier:
- according to guideline
- Guideline:
- other: EU method A.6 ("Water solubility“), Council Regulation (EC) No 440/2008
- Qualifier:
- according to guideline
- Guideline:
- other: OECD Guideline for the testing of chemicals, 105 "Water Solubility“, dated 27. Jul. 1995
- Version / remarks:
- 27. Jul. 1995
- Principles of method if other than guideline:
- Water solubility and hydrolysis of the test item were assessed in a combined conduct.
Due to the properties of the test item (e. g. rapid hydrolysis in contact with water), these standard test guidelines were not generally applicable and substantial modifications were necessary. Detailed information on the methods used are given in the following sections. - GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- Storage: in freezer (-25 °C to -15 °C)
- Radiolabelling:
- no
- Analytical monitoring:
- yes
- Details on sampling:
- Sample Order: Rinse solution 1 and 2 were analysed before and after each measurement of a sample or calibration solution to ensure a clean system and to avoid carry over effects.
- Buffers:
- pH 4, citrate buffer (c = 0.5 mol/L)
pH 7, phosphate buffer (c = 0.5 mol/L)
pH 9, borate buffer (c = 0.5 mol/L) - Details on test conditions:
- TEST SYSTEM
- Type, material and volume of test flasks, other equipment used: volumetric flasks with stoppers
- Details on test procedure for unstable compounds: The untreated test item was handled in an inert and anhydrous atmosphere (glove bag under nitrogen). Moreover, the test item was weighed into previously dried volumetric flasks with stoppers.
- If no traps were used, is the test system closed (volumetric flask with stoppers)
TEST MEDIUM
- Preparation of test medium: a stock solution was prepared as follows
Stock solution II (as named in the report): The test item was exactly weighed (individual weights are given in Table 1) into a tared 50.0 mL volumetric flask. Then, approx. 30 mL buffer was added whilst agitating with a magnetic stirrer and cooling in a water bath with frozen thermal packs for about 30 minutes. Thereafter, the solution was ultrasonicated for five minutes, allowed to equilibrate to room temperature and filled to volume with buffer solution. The turbid solution was transferred into a 50 mL centrifuge tube and centrifuged for 10 min with rcfmin ≈ 550. The supernatant was membrane-filtrated (0.45 µm, PTFE).
- Dilutions of the stock solutions were prepared as follows:
* Test Item in Buffer Solution - Dilution VII (as named in the report): 5 mL of the filtrate of the stock solution ll was pipetted into a 25.0 mL volumetric flask which was previously filled with 2.5 mL stabiliser solution. Approx. 10 mL of water was added and the solution was mixed. Subsequently,
2.5 mL of reference item no. 2 (i.e., the internal Tantalum ICP Standard) was added and the flask was filled to volume with water, resulting in a dilution factor of 5.
* Test Item in Buffer Solution - Dilution VIII (as named in the report): 100 µL of dilution VII was mixed in a plastic tube with 9.9 mL diluent, resulting in an overall dilution factor of 500.
* Test Item in Buffer Solution - Dilution IX (as named in the report): 100 µL of dilution VIII was mixed in a plastic tube with 9.9 mL diluent, resulting in an overall dilution factor of 50 000.
The solution was used for analysis via ICP-MS.
OTHER TEST CONDITIONS
- Adjustment of pH: no pH adjustment in the buffer solutions necessary - Duration:
- 1 h
- pH:
- 4
- Temp.:
- 25 °C
- Initial conc. measured:
- > 49.8 - < 66 µg/L
- Remarks:
- nominal concentration of tungsten in sample solution
- Duration:
- 1 h
- pH:
- 7
- Temp.:
- 25 °C
- Initial conc. measured:
- > 53.9 - < 62.2 µg/L
- Remarks:
- nominal concentration of tungsten in sample solution
- Duration:
- 1 h
- pH:
- 9
- Temp.:
- 25 °C
- Initial conc. measured:
- > 52.2 - < 63.2 µg/L
- Remarks:
- nominal concentration of tungsten in sample solution
- Number of replicates:
- 5
- Positive controls:
- no
- Negative controls:
- no
- Preliminary study:
- In a pre-test tungsten hexachloride showed a rapid hydrolysis in contact with aqueous solutions. A temperature rise during the addition of aqueous solutions was observed due to the exothermic reaction. The dispersion of the tungsten hexachloride with water was acidic (pH-value 2 to 3) and an insoluble residue sedimented on the ground.
- Transformation products:
- yes
- Remarks:
- partially
- No.:
- #1
- Details on hydrolysis and appearance of transformation product(s):
- - Rapid hydrolysis in contact with buffer solutions (pH 4, 7, 9)
- Temperature rise during the addition of aqueous solutions
- In buffered solutions the test item was completely dissolved (in pure water an insoluble residue occured, also after adjustment of pH to 4, 7, and 9). - % Recovery:
- ca. 96.9
- St. dev.:
- 8.1
- pH:
- 4
- Temp.:
- 25 °C
- Duration:
- < 1 h
- Remarks on result:
- other: in buffer solution
- % Recovery:
- ca. 88.9
- St. dev.:
- 6.1
- pH:
- 7
- Temp.:
- 25 °C
- Duration:
- < 1 h
- Remarks on result:
- other: in buffer solution
- % Recovery:
- ca. 94.3
- St. dev.:
- 1.1
- pH:
- 9
- Temp.:
- 25 °C
- Duration:
- < 1 h
- Remarks on result:
- other: in buffer solution
- pH:
- 4
- Temp.:
- 25 °C
- DT50:
- < 1 h
- Remarks on result:
- not determinable because of methodological limitations
- Remarks:
- hydrolysed completely within 1 hour
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- < 1 h
- Remarks on result:
- not determinable because of methodological limitations
- Remarks:
- hydrolysed completely within 1 hour
- pH:
- 9
- Temp.:
- 25 °C
- DT50:
- < 1 h
- Remarks on result:
- not determinable because of methodological limitations
- Remarks:
- hydrolysed completely within 1 hour
- Details on results:
- TEST CONDITIONS
- pH, sterility, temperature, and other experimental conditions maintained throughout the study: pH was stabilized in buffered solutions, temperature was in a range of 20 to 25 °C (deviation from OECD 111 demanding a range of 20.0 ± 0.5 °C); conditions of sterility are not mentioned, as well as light conditions
- Anomalies or problems encountered (if yes): The test item showed a rapid hydrolysis in contact with aqueous solutions. A temperature rise during the addition of aqueous solutions was observed due to the exothermic reaction. The dispersion of the WCl6 test item with water was acidic (pH-value 2 - 3) and an insoluble residue sedimented on the ground. In the buffered solution no precipitation was observed.
MAJOR TRANSFORMATION PRODUCTS
At pH 4, 7 and 9: soluble tungsten ions
For further details on results see table 1 below. - Validity criteria fulfilled:
- not specified
- Conclusions:
- Tungsten hexachloride reacts strongly with water. Hydrolysis takes place immediately, hence no exact dissipation half-life or degradation time was determined.
- Executive summary:
Hydrolysis of tungsten hexachloride at nominal concentrations of 49.8 to 66.0 µg/L was studied at 20 to 25 ºC in aqueous buffered solutions at pH 4 (citrate buffer, c = 0.5 mol/L), pH 7 (phosphate buffer, c = 0.5 mol/L) and pH 9 (borate buffer, c = 0.5 mol/L). The GLP experiment was conducted in a combined approach, investigating water solubility of the test item (acc. to OECD 105) and hydrolysis in dependence of pH (acc. to OECD 111). Samples were analysed immediately after dissolution of the test item in buffer solutions and subsequent ICP-MS analysis.
The determined concentrations of tungsten in the sample solution after preparation of the test item in citrate buffer (pH 4) ranged from 41.7 µg/L to 66.5 µg/L, corresponding to a mean recovery of 96.9 ± 8.1 %. The determined concentrations of tungsten in the sample solution after preparation of the test item in phosphate buffer (pH 7) varied between 43.3 to 59.4 µg/L, corresponding to a mean recovery of 88.9 ± 6.1 %. The determined concentrations of tungsten in the sample solution after preparation of the test item in borate buffer (pH 9) ranged between 48.9 to 58.7 µg/L, corresponding to a mean recovery of 94.3 ± 1.1 %.
In summary tungsten hexachloride shows a rapid hydrolysis in contact with aqueous solutions. This exothermic reaction results in a temperature rise of the test solutions. Tungsten hexachloride was almost completely dissolved in the three buffer solutions at pH 4, 7 and 9.
This study is classified acceptable and satisfies the guideline requirement for hydrolysis study.
Reference
Table 1: The following table represents the results obtained from each analysis of the fivefold preparation of the test item in three different buffer solutions.
Preparation # |
pH value |
Sample mass [mg] |
Nominal concentration of tungsten in sample solution [µg/L] |
Actual concentration of tungsten in sample solution [µg/L] |
Recovery of tungsten in sample solution [%] |
1 |
4 |
334 |
62.0 |
65.3 |
105.4 |
2 |
349 |
64.8 |
62.4 |
96.3 |
|
3 |
356 |
66.0 |
66.5 |
100.8 |
|
4 |
268 |
49.8 |
41.7 |
83.8 |
|
5 |
354 |
65.6 |
64.4 |
98.3 |
|
|
|
|
|
|
|
|
|
|
|
Mean |
96.9 |
|
|
|
|
SD |
8.1 |
|
|
|
|
RSD [%] |
8.4 |
|
|
|
|
|
|
|
|||||
|
|
|
|
|
|
1 |
7 |
291 |
53.9 |
43.3 |
80.4 |
2 |
316 |
58.5 |
52.0 |
88.7 |
|
3 |
296 |
54.9 |
47.2 |
86.0 |
|
4 |
300 |
55.6 |
52.2 |
94.0 |
|
5 |
335 |
62.2 |
59.4 |
95.5 |
|
|
|
|
|
|
|
|
|
|
|
Mean |
88.9 |
|
|
|
|
SD |
6.1 |
|
|
|
|
RSD [%] |
6.9 |
|
|
|
|
|
|
|
|||||
|
|
|
|
|
|
1 |
9 |
305 |
56.6 |
53.2 |
94.0 |
2 |
311 |
57.6 |
54.8 |
95.1 |
|
3 |
291 |
54.0 |
51.6 |
95.6 |
|
4 |
341 |
63.2 |
58.7 |
92.9 |
|
5 |
282 |
52.2 |
48.9 |
93.7 |
|
|
|
|
|
|
|
|
|
|
|
Mean |
94.3 |
|
|
|
|
SD |
1.1 |
|
|
|
|
RSD [%] |
1.2 |
Description of key information
A study on hydrolysis which was conducted according to the OECD guideline 111 is available. Results from a pre-test showed that tungsten hexachloride reacts exothermic with water and a pH shift (2 to 3) occurs upon dissolution. The main test was conducted with tungsten hexachloride in buffered solutions with concentrations of tungsten at 49.8 to 66.0 µg a.i./L was at 20 to 25 ºC: pH 4 (citrate buffer, c = 0.5 mol/L), pH 7 (phosphate buffer, c = 0.5 mol/L) and pH 9 (borate buffer, c = 0.5 mol/L) for less than an hour. Samples were analysed immediately after dissolution of the test item in buffer solutions by diluting the solution and directly injecting it to ICP-MS. ICP-MS identified tungsten (VI) oxide as main transformation product.
As hydrolysis takes place immediately, hence no dissipation half-life or degradation time was determined.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.