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Ecotoxicological information

Toxicity to microorganisms

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Reference
Endpoint:
activated sludge respiration inhibition testing
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from peer reviewed journal
Qualifier:
according to
Guideline:
ISO 8192 (Water quality - Test for inhibition of oxygen consumption by activated sludge for carbonaceous and ammonium oxidation)
GLP compliance:
not specified
Analytical monitoring:
not specified
Vehicle:
not specified
Test organisms (species):
activated sludge
Test type:
not specified
Water media type:
not specified
Total exposure duration:
30 min
Reference substance (positive control):
not specified
Key result
Duration:
30 min
Dose descriptor:
EC0
Effect conc.:
100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
other: O2 consumption
Key result
Duration:
30 min
Dose descriptor:
EC50
Effect conc.:
> 100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
other: O2 consumption
Validity criteria fulfilled:
not specified
Conclusions:
Based on effect on oxygen consumption of the test organism activated sludge, the 30 mins EC0 and EC50 value was determined to be 100 mg/l and > 100 mg/l, respectively.
Executive summary:

Toxicity to activated sludge study was carried out for 30 mins. The study was performed in accordance with the ISO 8192 (Water quality - Test for inhibition of oxygen consumption by activated sludge for carbonaceous and ammonium oxidation). On the basis of the effect on oxygen consumption of the test organism activated sludge, the 30 mins EC0 and EC50 value was determined to be 100 mg/l and > 100 mg/l, respectively.

Description of key information

Toxicity to activated sludge study was carried out for 30 mins (Udo Pagga et. al., 1994). The study was performed in accordance with the ISO 8192 (Water quality - Test for inhibition of oxygen consumption by activated sludge for carbonaceous and ammonium oxidation). On the basis of the effect on oxygen consumption of the test organism activated sludge, the 30 mins EC0 and EC50 value was determined to be 100 mg/l and > 100 mg/l, respectively.

Key value for chemical safety assessment

EC10 or NOEC for microorganisms:
100 mg/L

Additional information

Various experimental studies of the test chemical and supporting study for its read across chemical were reviewed for toxicity to microorganism end point which are summarized as below:

 

In an experimental key study (Udo Pagga et. al., 1994), toxicity to activated sludge study was carried out for 30 mins. The study was performed in accordance with the ISO 8192 (Water quality - Test for inhibition of oxygen consumption by activated sludge for carbonaceous and ammonium oxidation). On the basis of the effect on oxygen consumption of the test organism activated sludge, the 30 mins EC0 and EC50 value was determined to be 100 mg/l and > 100 mg/l, respectively.

 

For the test chemical, toxicity to Tetrahymena pyriformis study was carried out (Handbook, 2008). The study was based on the effects of the test chemical on test organism. On the basis of effect of test chemical on test organism, the 24 hr LC100 value was determined to be 400 mg/l.

 

On the basis of the above results, it can be concluded that the test chemical can be considered to be non-toxic to microorganisms.