Registration Dossier
Registration Dossier
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EC number: 203-628-5 | CAS number: 108-90-7
Endpoint summary
Administrative data
Description of key information
In studies in rats and mice, chlorobenzene was fatal after acute, intermediate and chronic oral administration. Rats of both sexes and mice died within 2-3 days of single exposure to, respectively, 4000 mg / kg and 1000 mg / kg of the substance in corn oil. However, no histological or necroscopic examinations were performed on the treated animals.
Chlorobenzene is not considered to cause serious health effects due to repeated oral exposure, NOAEL of 125 mg / kg body weight. The substance should also not cause severe health effects by repeated exposure by inhalation.
Key value for chemical safety assessment
Additional information
Australian Government. Department of Health. National Industrial Chemicals Notification and Assessment Scheme (NICNAS). HUMAN HEALTH TIER II ASSESSMENT FOR Benzene, chloro-.
Justification for classification or non-classification
The intermediate not met GHS criteria.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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