Registration Dossier

Registration Dossier

Diss Factsheets

Administrative data

Description of key information

Acute toxicity (oral): LD50 rat > 2000 mg/kg (OECD 401), transient ataxia, laborious breathing, hyperpnea (greater depth of respiratory acts), prostration. (*)
                           LD50 rat = 1110 - 2290 mg/kg (**)

Acute toxicity (dermal): LD50 rabbit > 2200 mg/kg (***)

Acute toxicity (inhalation): LC50 rat = 15.5 mg/L/4 hours (comparable study with OECD 403) (****)
LC50 rat = 16.1 mg/L/ 4 hours
LC50 rat = 29.6 mg/L/4 hours (OECD 403)

Key value for chemical safety assessment

Acute toxicity: via inhalation route

Link to relevant study records
Reference
Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
GLP compliance:
not specified
Remarks:
not specified
Test type:
other: not specified
Species:
rat
Strain:
not specified
Sex:
not specified
Sex:
not specified
Dose descriptor:
LC50
Effect level:
15.5 mg/L air
Exp. duration:
4 h
Remarks on result:
other: omparable study with OECD 403
Sex:
not specified
Dose descriptor:
LC50
Effect level:
16.1 mg/L air
Exp. duration:
4 h
Sex:
not specified
Dose descriptor:
LC50
Effect level:
29.6 mg/L air
Exp. duration:
4 h
Remarks on result:
other: OECD 403
Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
The intermediate is classified as harmful if inhaled (CLP Regulation - category 4)
Endpoint conclusion
Endpoint conclusion:
adverse effect observed

Additional information

Bibliographic source:

(*) Australian Government. Department of Health. National Industrial Chemicals Notification and Assessment Scheme (NICNAS). HUMAN HEALTH TIER II ASSESSMENT FOR Benzene, chloro-.

(**) Toxicology Data Network (TOXNET). HSDB: Chlorobenzene.

(***) Toxicology Data Network (TOXNET). ChemIDplus: Chlorobenzene.

(****) CLH report for Chlorobenzene. Proposal for Harmonised Classification and Labelling.

Justification for classification or non-classification

The substance is classified as harmful if swallowed. (CLP Regulation - category 4)

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