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Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Acute toxicity (oral): LD50 rat > 2000 mg/kg (OECD 401), transient ataxia, laborious breathing, hyperpnea (greater depth of respiratory acts), prostration. (*)
                           LD50 rat = 1110 - 2290 mg/kg (**)

Acute toxicity (dermal): LD50 rabbit > 2200 mg/kg (***)

Acute toxicity (inhalation): LC50 rat = 15.5 mg/L/4 hours (comparable study with OECD 403) (****)
LC50 rat = 16.1 mg/L/ 4 hours
LC50 rat = 29.6 mg/L/4 hours (OECD 403)

Key value for chemical safety assessment

Acute toxicity: via inhalation route

Link to relevant study records
Reference
Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
GLP compliance:
not specified
Remarks:
not specified
Test type:
other: not specified
Species:
rat
Strain:
not specified
Sex:
not specified
Sex:
not specified
Dose descriptor:
LC50
Effect level:
15.5 mg/L air
Exp. duration:
4 h
Remarks on result:
other: omparable study with OECD 403
Sex:
not specified
Dose descriptor:
LC50
Effect level:
16.1 mg/L air
Exp. duration:
4 h
Sex:
not specified
Dose descriptor:
LC50
Effect level:
29.6 mg/L air
Exp. duration:
4 h
Remarks on result:
other: OECD 403
Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
The intermediate is classified as harmful if inhaled (CLP Regulation - category 4)
Endpoint conclusion
Endpoint conclusion:
adverse effect observed

Additional information

Bibliographic source:

(*) Australian Government. Department of Health. National Industrial Chemicals Notification and Assessment Scheme (NICNAS). HUMAN HEALTH TIER II ASSESSMENT FOR Benzene, chloro-.

(**) Toxicology Data Network (TOXNET). HSDB: Chlorobenzene.

(***) Toxicology Data Network (TOXNET). ChemIDplus: Chlorobenzene.

(****) CLH report for Chlorobenzene. Proposal for Harmonised Classification and Labelling.

Justification for classification or non-classification

The substance is classified as harmful if swallowed. (CLP Regulation - category 4)