Registration Dossier

Registration Dossier

Diss Factsheets

Administrative data

Description of key information

0.1 mL of chlorobenzene was instilled into the conjunctival sac of 3 rabbits, one eye per animal was treated (OECD 405). The mean scores of the results recorded at 24, 48 and 72 hours were: 0.1 for corneal opacity, 0.9 for conjunctival redness, 0.4 for chemosis, and 0 for iritis. The effects were totally reversible within 7 days.

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records
Reference
Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
GLP compliance:
not specified
Remarks:
not specified
Species:
rabbit
Strain:
not specified
Type of coverage:
occlusive
Preparation of test site:
shaved
Vehicle:
unchanged (no vehicle)
Amount / concentration applied:
0.5 mL / 99.0 % (w/w)
Duration of treatment / exposure:
4 hours
Observation period:
14 days
Number of animals:
3
Irritation parameter:
erythema score
Basis:
mean
Time point:
24/48/72 h
Score:
2.7
Max. score:
4
Reversibility:
fully reversible within: 6 days
Remarks on result:
positive indication of irritation
Irritation parameter:
edema score
Basis:
mean
Time point:
24/48/72 h
Score:
1
Max. score:
4
Reversibility:
fully reversible within: 6 days
Remarks on result:
positive indication of irritation
Interpretation of results:
Category 2 (irritant) based on GHS criteria
Conclusions:
The intermediate is classified as causes skin irritation (CLP Regulation - category 2)
Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

Bibliographic source:

CLH report for Chlorobenzene. Proposal for Harmonised Classification and Labelling.

REACH Registration Dossier: Chlorobenzene.

Justification for classification or non-classification

The substance is classified as causes skin irritation (CLP Regulation - category 2)

EU Privacy Disclaimer

This website uses cookies to ensure you get the best experience on our websites.