Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
publication
Title:
CLH report for Chlorobenzene. Proposal for Harmonised Classification and Labelling
Year:
2013
Bibliographic source:
CLH report. Proposal for Harmonised Classification and Labelling.

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
GLP compliance:
not specified
Remarks:
not specified
Test type:
other: not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Chlorobenzene
EC Number:
203-628-5
EC Name:
Chlorobenzene
Cas Number:
108-90-7
Molecular formula:
C6H5Cl
IUPAC Name:
chlorobenzene
Test material form:
not specified

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Results and discussion

Effect levelsopen allclose all
Sex:
not specified
Dose descriptor:
LC50
Effect level:
15.5 mg/L air
Exp. duration:
4 h
Remarks on result:
other: omparable study with OECD 403
Sex:
not specified
Dose descriptor:
LC50
Effect level:
16.1 mg/L air
Exp. duration:
4 h
Sex:
not specified
Dose descriptor:
LC50
Effect level:
29.6 mg/L air
Exp. duration:
4 h
Remarks on result:
other: OECD 403

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
The intermediate is classified as harmful if inhaled (CLP Regulation - category 4)