Ethyl hexanoate

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2015-07-03 to 2015-07-08

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

GLP compliance:

yes (incl. QA statement)

Type of method:

flask method

Key result

Water solubility:

508 g/L

Conc. based on:

test mat. (dissolved fraction)

Loading of aqueous phase:

5 g/L

Incubation duration:

>= 24 - <= 72 h

Temp.:

30 °C

pH:

ca. 4.9

Details on results:

Preliminary test: The water solubility was determined to be in the range of 500-1000 mg/L

Table: Water Solubility Results at 20 °C

Preincubation time [h]	Replicate No.	Test item
		Concentration	Mean value
24	1	467	500
	2	503
48	1	528	523
	2	518
72	1	493	502
	2	512
Mean (24 - 72 h)			508
Deviation [%] (24 - 72 h)			4.60

Temperature at incubation phase, 30°C and thermostatisation phase, 20 °C (measured hourly 

Intended temperature	Measured temperature [°C]
	Min	Max	Mean value± SD
30±0.5	29.91	30.08	30.00±0.02
20±0.5	20.04	20.17	20.08±0.02

PH value

Test temperature [°C]	Pre-incubation time [h]	replicate	Measured pH	Mean value
20	24	1	4.770	4.9
		2	4.852
	48	1	5.056
		2	4.983
	72	1	4.967
		2	4.970
		control	6.437	-

 No tyndall effect was detected during the incubation time .

Validity criteria were fullfilled: The concentration measured did not differ more than 15%, tempreatures were kept constant within ± 0.5°C

Conclusions:

The water solubility of the test item was determined to be 508 mg/L (pH 4.9) at 20 ± 0.5 °C.

Executive summary:

The test item has a water solubility of 508 mg/L (pH 4.9) at 20 ± 0.5 °C as determined by flask method according to Regulation EC No. 440/2008 Method A.6., OECD Test Guideline 105 (1995).

Description of key information

The water solubility is 508 mg/L (pH 4.9) at 20 ± 0.5 °C.

Key value for chemical safety assessment

Water solubility:

508 mg/L

at the temperature of:

20 °C

Additional information

The test item has a water solubility of 508 mg/L (pH 4.9) at 20 ± 0.5 °C as determined by flask method according to Regulation EC No. 440/2008 Method A.6., OECD Test Guideline 105 (1995).