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EC number: 205-528-7
CAS number: 142-22-3
Table 1: Recovery % of test substance
* percent of applied 14C dose
** carbon dioxide was a pooled animal
*** site of IM (intramuscular) injection
The total percent recovery of the compound
was 109.7 (standard deviation of 3.1). The excess above 100% is due to
extremely low counts above background, large volumes of the tissue
homogenate preparations and the small aliquot utilized in the wet ashing
The 14C label on the CR-39 was predominately
excreted via respiration (70 .77% of the injected dose). Over 60% of the
dose was collected in the respired carbon dioxide within the first 24
hours from application.
Elimination of the 14C label on the CR-39
into the urine accounts for 19.9% (standard deviation of 1.0) of the
dose with 19% of the dose being eliminated within the first 24 hours
Two graphs are enclosed (see "Attached
background material"): The first is a linear plot of the average % dose
excreted into the urine per hour versus time at the midpoint of the
collection period. The second is a semilog plot of the % dose excreted
into the urine per hour versus time at the midpoint of the collection
This study was performed to determine the
excretion parameters of the allyl-14C1- label on diallyl-diglycol
carbonate (CR-39) into the urine, feces, and respired carbon dioxide as
well as deposition into the liver, kidney, thigh (site of injection),
and remaining carcass following a single parenteral dose utilizing the
guinea pig experimental animal model.
The percent recovery of the test substance
in parameters examined was 100% seven days after the administration.
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