Registration Dossier

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

In the "Delayed Contact Hypersensitivity Study In Guinea Pigs of CR-39 Monomer" (dated 1979-02-15) guinea pigs (10/sex) were dosed with 0.4 mL of carbonic acid, oxydiethylene diallyl ester to shaved intact skin under occluded conditions for 6 hours. Patches were reapplied to the same site of test animals once a week for a total of three applications. After a 2-week rest period, a fresh application site was challenged with 0.4 mL of the test substance as described previously. During the primary challenge, all 20 animals did not show any irritation at the 24- and 48-hour readings. Carbonic acid, oxydiethylene diallyl ester was not a skin sensitizer in guinea pigs.


Migrated from Short description of key information:
The "Delayed Contact Hypersensitivity Study In Guinea Pigs of CR-39 Monomer" (dated 1979-02-15) was performed prior to the adoption of the GLP regultaions as well as OECD Guidelines.

Justification for classification or non-classification

Skin sensitisation: the test substance was not a skin sensitizer in guinea pigs.

The classification is not warranted according to the criteria of EU Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulations No 1272/2008.

Respiratory sensitisation: no data