Registration Dossier

Administrative data

Endpoint:
in vitro gene mutation study in mammalian cells
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
grey literature
Title:
Development of standard protocol for in vitro cytogenetic testing with CHO cells: Comparison of results for 22 compounds in two laboratories
Author:
Galloway et al.
Year:
1985
Bibliographic source:
Environ. Mutagen Vol. 7 (1985) 1-52

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
EU Method B.19 (Sister Chromatid Exchange Assay In Vitro)
GLP compliance:
not specified
Type of assay:
other: sister chromatid assay in mammalian cells

Test material

Reference
Name:
Unnamed
Type:
Constituent

Method

Species / strain
Species / strain / cell type:
Chinese hamster Ovary (CHO)

Results and discussion

Test results
Species / strain:
Chinese hamster Ovary (CHO)
Metabolic activation:
not specified
Genotoxicity:
positive
Cytotoxicity / choice of top concentrations:
cytotoxicity

Applicant's summary and conclusion