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Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation: in vivo (LLNA)
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Toxicology of the Eye. 2nd Edition
Author:
Grant
Year:
1974
Bibliographic source:
Charles C. Thomas, Springfield Illinois, 1974, p. 859
Reference Type:
grey literature
Title:
NIOSH/OSHA - Occupational Health Guidelines for Chemical Hazards
Author:
Mackinson et al.
Year:
1981
Bibliographic source:
DHHS(NIOSH) Publication no. 81-13 (3. VOLS) Washington DC: US Government Printing Office, Jan. 1981
Reference Type:
publication
Title:
Use of the Albino Guinea-pig to detect the Skin-sensitizing ability of chemicals
Author:
Stevens MA
Year:
1967
Bibliographic source:
British Journal of industrial Methods

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 406 (Skin Sensitisation)
GLP compliance:
not specified
Type of study:
reduced LLNA

Test material

Reference
Name:
Unnamed
Type:
Constituent

In vivo test system

Test animals

Species:
guinea pig
Strain:
other: Alderly Park
Sex:
not specified

Study design: in vivo (LLNA)

Vehicle:
unchanged (no vehicle)
Concentration:
100 %

Results and discussion

In vivo (LLNA)

Results
Parameter:
other: Erythema Rating
Value:
ca. 2
Remarks on result:
other: 2 of 6 individuals exhibit pink erythema

Any other information on results incl. tables

Skin burns in human(s) result from contact for twenty min in 40% solution in water. Exposure to beta-propiolactone ca. cause irritation and blistering of the skin, hair loss and scarring.

Applicant's summary and conclusion