Registration Dossier
Registration Dossier
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EC number: 200-340-1 | CAS number: 57-57-8
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicology of the Eye. 2nd Edition
- Author:
- Grant
- Year:
- 1 974
- Bibliographic source:
- Charles C. Thomas, Springfield Illinois, 1974, p. 859
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Propiolactone
- EC Number:
- 200-340-1
- EC Name:
- Propiolactone
- Cas Number:
- 57-57-8
- Molecular formula:
- C3H4O2
- IUPAC Name:
- oxetan-2-one
Constituent 1
Results and discussion
In vivo
Results
- Irritation parameter:
- other: Skin burning
- Time point:
- other: 20 min
- Score:
- ca. 100
- Irritant / corrosive response data:
- Human skin burns from contact for twenty minutes with 40% solution of propiolactone in water
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
