Registration Dossier
Registration Dossier
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EC number: 248-654-8 | CAS number: 27776-01-8
Endpoint summary
Administrative data
Description of key information
Benzyltoluene is not expected to undergo hydrolysis, based on its structural properties.
One ready biodegradability tests carried out according to OECD guidelines have been carried out. Based on these results, it can be concluded that benzyltoluene is not readily biodegradable.
Log Koc has been estimated by HPLC to be (2 isomers): 3.6 and 3.7. The mean is used as key parameter.
The registered substance contains concentration > 0.1 % of a PBT/ vPvB compound. According to the Echa Guidance R11related to the PBT/vPvB assessment, in that case, the registered substance has to be considered also as a PBT/vPvB substance.
To answer the CCH-D-2114527842-47-01/F about the persistency datagap in the Benzyltoluene dossier, the studies performed on the relevant impurity (Dibenzyltoluene: CAS 53585-53-8) were added in section 5.2.2. Moreover, the section 5.3.1 has been completed with the available data on bioaccumulation for this relevant impurity (Dibenzyltoluene).
Additional information
Biotic degradation on relevant impurity:
An aerobic mineralization study (OECD 309) was conducted with [14C]DBT Test Substances using aerobic natural water with amended solids. The tests were performed at 12°C. Two relevant compounds of DBT substance were radiolabelled : o,m-DBT, o,o-DTPM and one relevant impurity.
The half-life of DBT during the study was determined as 56.9 days for o,m-DBT, >10,000 days for o,o-DTPM, and 32.8 days for the relevant impurity (SFO model).
Degradation products were observed throughout the study in two out of the three labels. Unknown metabolites were detected in o,m-DBT and the relevant impurity and was tentatively analyzed by LC-MS/MS.
Based on this study, o,m-DBT can be considered as persistent and o,o-DTPM can be considered as persistent /very persistent.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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