Registration Dossier
Registration Dossier
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EC number: 245-010-8 | CAS number: 22457-23-4
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- no details on the method are available.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 5-methylheptan-3-one oxime
- EC Number:
- 245-010-8
- EC Name:
- 5-methylheptan-3-one oxime
- Cas Number:
- 22457-23-4
- Molecular formula:
- C8H17NO
- IUPAC Name:
- 5-methylheptan-3-one oxime
- Reference substance name:
- (E)-3,4-dimethylhexan-2-one oxime
- IUPAC Name:
- (E)-3,4-dimethylhexan-2-one oxime
- Reference substance name:
- (Z)-3,4-dimethylhexan-2-one oxime
- IUPAC Name:
- (Z)-3,4-dimethylhexan-2-one oxime
- Test material form:
- liquid
Constituent 1
impurity 1
impurity 2
- Specific details on test material used for the study:
- Sample Marking: 76-362, Stemone
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Duration of exposure:
- 14 d
- Doses:
- 2.5 g/kg
5.0 g/kg - No. of animals per sex per dose:
- 4 @ 2.5 g/kg
8 @ 5 g/kg - Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
Any other information on results incl. tables
| Dose (g/Kg) | Deaths / No. of Anmials | Observation Day | |||||||||||||
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | ||
| 2.5 | 0/4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 5.0 | 2/8 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Slight redness in 1 at 5.0 g/kg
Moderate redness in others
Slight edema in 2 at 2.5 g/kg and 2 at 5.0 g/kg
Moderate edema in others
Necropsy - portion of small intestine reddened and evidence of diarrhea prior to death in 1.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Dermal LD50 shown to be above 5000 mg/kg.
- Executive summary:
An acute dermal toxicity study was carried out on Rabbits, the LD 50 was determined to be greater than the highest test dose of 5000 mg/kg, therefore the substance can be considered as not classified according to CLP criteria.
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