Registration Dossier
Registration Dossier
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EC number: 245-010-8 | CAS number: 22457-23-4
Endpoint summary
Administrative data
Description of key information
Short-term aquatic toxicity data are available for each of the three freshwater trophic levels (fish, daphnia and algae). Experimental studies are available for daphnia (EC50 = 44 mg/L) and for algal inhibition (ErC50 = 62mg/L, NOEC = 10 mg/L). In the absence of experimental data, the acute toxicity to fish has been assessed using a QSAR approach. The QSAR approach works within the spirit of REACH and the stated aim of the legislation to reduce animal testing where possible. The predicted fish 96-hr LC50 value using the ECOSAR v1.11 Neutral Organic SAR is 51.451 mg/L. The applicability of the Neutral Organic SAR class to the prediction of aquatic toxicity for the registration substance is supported by a comparison of predicted and measured values for the daphnia and algae endpoints. The predicted daphnia 48h EC50 is 30 mg/L (measured value = 44 mg/L) and the predicted green algae 96h EC50 is 26 mg/L (measured 72h value is 62mg/L).
Toxicity to microorganisms was assessed as part of a standardised ready biodegradation test. The substance did not inhibit degradation of the positive control at a test concentration of 100mg/L. Thus this concentration can be considered the NOEC for toxicity to STP microorganisms.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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