Registration Dossier
Registration Dossier
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EC number: 245-010-8 | CAS number: 22457-23-4
Endpoint summary
Administrative data
Description of key information
Assessment of hydrolytic stability was carried out according to OECD Guideline 111. The substance is considered to be hydrolytically stable at pH 7 and pH 9. Hydrolysis was observed at pH 4 with an estimated half-life of 14.7 hours at 25°C.
Information on phototransformation in air, water and soil is not available. It is not a standard information requirement under REACH and there is no indication from the CSA on the need to investigate further the fate and behaviour of the substance.
Stemone is considered not to be readily biodegradable or inherently biodegradable based on two OECD 301F ready tests and one OECD 302C inherent test. Thus for the purpose of the chemical safety assessment the conclusion is that "under test conditions no biodegradation was observed". As such the biodegradation rate constant used for the environmental exposure assessment, performed using Chesar, is zero. For the purpose of the PBT assessment, the substance is considered as having potential P/vP properties. Further information, such as an appropriate simulation test and/or identification of primary degradation products, would be required to definitively conclude on the P / vP properties of the substance. Such testing is not proposed as the substance is not B/vB based on the logKow of <4.5. Neither is there evidence of T properties. As such the substance is neither PBT of vPvB.
Stemone is not considered to be potentially bioaccumulative based on a log Pow of 2.2 and 2.4 for the purposes of classification and labelling (criterion is ≥ 4) and for the PBT assessment (criterion is > 4.5). The low octanol water partition coefficient also indicates that Stemone is expected to have low potential for adsorption to soil and sediment. Thus in accordance with column 2 of the REACH Annexes VIII and IX, a study to assess adsorption/ desorption has not been performed. Instead the Koc has been estimated from Kow for the purposes of environmental exposure assessment and derivation of PNECsoil and PNECsediment.
Henry's Law constant is required for exposure assessment and derivation of PNECsoil. It has been estimated from molecular weight (143 Mwt; g/mol), water solubility (S; 1060 mg/L at 20'C) and vapour pressure (VP; 5.32 Pa at 20'C) using the relationship: H= (VP x Mwt) / S.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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