4,7-dichloroquinoline

Partition coefficient

Link to relevant study record(s)

Reference

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Justification for type of information:

Experimental test result performed using standard OECD test guidelines

Qualifier:

according to guideline

Guideline:

OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)

GLP compliance:

no

Type of method:

HPLC method

Partition coefficient type:

octanol-water

Analytical method:

high-performance liquid chromatography

Key result

Type:

log Pow

Partition coefficient:

3.193

Temp.:

25 °C

pH:

4.1

Remarks on result:

other: logKow was reported to be 3.193 ± 0.001

Details on results:

The Partition coefficient (Pow) of the test chemical was determined to be 3.193 ± 0.001 at 25°C

Table:

Test substance		K	Log k	Log Pow by Generalized Calibration Graph	Mean of Log Pow ± S.D.
Rt1	2.371	1.521	0.182	3.192	3.193 ± 0.001
Rt2	2.373	1.524	0.183	3.193

Conclusions:

The partition coefficient (n-octanol/water) of test chemical was determined as per the HPLC method (OECD Guideline-117). The Log Pow value was determined to be 3.193 ± 0.001 dimensionless at 25°.

Executive summary:

The partition Coefficient n-octanol/water of test chemical was determined by the Reverse Phase High Performance Liquid Chromatographic method according to OECD Guideline No. 117 for testing of Chemicals. A test chemical solution was prepared by accurately weighing 4 mg of test chemical and diluted with Acetonitrile up to 10 ml. Thus, the test solution concentration was 400 mg/l. The pH of test substance was 4.1. The reference substances were chosen according to functional similarity with the test substance and calibration graph was prepared . The reference substances were Phenol, Benzene, 1,4-Dichlorobenzene, 1,2,4-Trichlorobenzene, Chlorobenzene, Bromobenzene, 2-Nitrophenol, Nitrobenzene having Pow value ranging from 1.5 to 4.2. The Log Pow value was determined to be 3.193 ± 0.001 dimensionless at 25°.

Description of key information

The partition Coefficient n-octanol/water of test chemical was determined by the Reverse Phase High Performance Liquid Chromatographic method according to OECD Guideline No. 117 for testing of Chemicals. A test chemical solution was prepared by accurately weighing 4 mg of test chemical and diluted with Acetonitrile up to 10 ml. Thus, the test solution concentration was 400 mg/l. The pH of test substance was 4.1. The reference substances were chosen according to functional similarity with the test substance and calibration graph was prepared . The reference substances were Phenol, Benzene, 1,4-Dichlorobenzene, 1,2,4-Trichlorobenzene, Chlorobenzene, Bromobenzene, 2-Nitrophenol, Nitrobenzene having Pow value ranging from 1.5 to 4.2. The Log Pow value was determined to be 3.193 ± 0.001 dimensionless at 25°C.

Key value for chemical safety assessment

Log Kow (Log Pow):

3.193

at the temperature of:

25 °C

Additional information

The partition Coefficient n-octanol/water of test chemical was determined by the Reverse Phase High Performance Liquid Chromatographic method according to OECD Guideline No. 117 for testing of Chemicals. A test chemical solution was prepared by accurately weighing 4 mg of test chemical and diluted with Acetonitrile up to 10 ml. Thus, the test solution concentration was 400 mg/l. The pH of test substance was 4.1. The reference substances were chosen according to functional similarity with the test substance and calibration graph was prepared . The reference substances were Phenol, Benzene, 1,4-Dichlorobenzene, 1,2,4-Trichlorobenzene, Chlorobenzene, Bromobenzene, 2-Nitrophenol, Nitrobenzene having Pow value ranging from 1.5 to 4.2. The Log Pow value was determined to be 3.193 ± 0.001 dimensionless at 25°C.

Based on the data obtained from various reliable sources, the octanol-water partition coefficient (log Pow) of the test chemical was determined to be 3.57.

Thus based on the above data, the log Pow was ranges from 3.193 to 3.57.