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Environmental fate & pathways

Hydrolysis

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Reference
Endpoint:
hydrolysis
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
Experimental data of read across chemicals
Justification for type of information:
data from handbook or collection of data
Reason / purpose for cross-reference:
read-across source
Reason / purpose for cross-reference:
read-across source
Qualifier:
according to guideline
Guideline:
other: Refer below principle
Principles of method if other than guideline:
WoE was prepared from two studies for the determination of half life of test chemical.
GLP compliance:
not specified
Radiolabelling:
not specified
Analytical monitoring:
not specified
Positive controls:
not specified
Negative controls:
not specified
Transformation products:
not specified
Key result
pH:
7
Temp.:
25 °C
Hydrolysis rate constant:
< 0.9 min-1
DT50:
> 879 yr
Type:
(pseudo-)first order (= half-life)
Remarks on result:
other: Other details not known
Remarks:
WoE: 2
pH:
4
DT50:
75 d
Remarks on result:
other: Test chemical was stable to hydrolysis at pH 7 and pH 9
Remarks:
WoE: 2
Validity criteria fulfilled:
not specified
Conclusions:
The pseudo first order hydrolysis rate constant of test chemical was determined to be < 0.9 m/hr with a corresponding half-lives off > 879 years at pH 7 and a temperature of 25°C, respectively.
The half-life period of test chemical was determined to be 75 days at pH 4 and thus test chemical was reported to be hydrolytically stable at pH 7 and 9.
On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from 75 days to >879 yr, at pH range 4 and 7, respectively. Thus, based on this half-life value, it can be concluded that the test chemical is expected to be stable in water.
Executive summary:

Data available for the test chemical has been reviewed to determine the half-life of hydrolysis as a function of pH. The studies are as mentioned below:

The half-life of the test chemical was determined at different. The study was performed at pH 7 & at a temperature of 25°C, respectively. The pseudo first order hydrolysis rate constant of test chemical was determined to be < 0.9 m/hr with a corresponding half-lives of >879 years at pH 7 and a temperature of 25°C, respectively. Based on the half-life values, it is concluded that the chemical was not hydrolysable.

Above study further supported by the third weight of evidence study from authoritative database. The half-life of the test chemical was determined at different pH range. The study was performed at pH of 4, 7 and 9. The half-life period of test chemical was determined to be 75 days at pH 4 and thus test chemical was reported to be hydrolytically stable at pH 7 and 9. On the basis of this, test chemical was considered to be not hydrolysable.

On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from 75 days to >879 yr, at pH range 4 and 7, respectively. Thus, based on this half-life value, it can be concluded that the test chemical is expected to be stable in water.

Description of key information

The pseudo first order hydrolysis rate constant of test chemical was determined to be < 0.9 m/hr with a corresponding half-lives off > 879 years at pH 7 and a temperature of 25°C, respectively.

The half-life period of test chemical was determined to be 75 days at pH 4 and thus test chemical was reported to be hydrolytically stable at pH 7 and 9.

On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from 75 days to >879 yr, at pH range 4 and 7, respectively. Thus, based on this half-life value, it can be concluded that the test chemical is expected to be stable in water.

Key value for chemical safety assessment

Half-life for hydrolysis:
75 d

Additional information

Data available for the test chemical and structually and functionally similar read across chemicals has been reviewed to determine the half-life of hydrolysis as a function of pH. The studies are as mentioned below:

The half-life of the test chemical was determined at different. The study was performed at pH 7 & at a temperature of 25°C, respectively. The pseudo first order hydrolysis rate constant of test chemical was determined to be < 0.9 m/hr with a corresponding half-lives of >879 years at pH 7 and a temperature of 25°C, respectively. Based on the half-life values, it is concluded that the chemical was not hydrolysable.

Above study further supported by the third weight of evidence study from authoritative database. The half-life of the test chemical was determined at different pH range. The study was performed at pH of 4, 7 and 9. The half-life period of test chemical was determined to be 75 days at pH 4 and thus test chemical was reported to be hydrolytically stable at pH 7 and 9. On the basis of this, test chemical was considered to be not hydrolysable.

On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from 75 days to >879 yr, at pH range 4 and 7, respectively. Thus, based on this half-life value, it can be concluded that the test chemical is expected to be stable in water.