Registration Dossier
Registration Dossier
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EC number: 206-033-9 | CAS number: 294-62-2
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Adequacy of study:
- other information
- Study period:
- 09/1964
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 964
Materials and methods
- Type of study / information:
- Liver function tests
Test guideline
- Qualifier:
- no guideline followed
- Deviations:
- not applicable
- Principles of method if other than guideline:
- not described; further information see in section "Method"
- GLP compliance:
- no
Test material
- Reference substance name:
- Cyclododecane
- EC Number:
- 206-033-9
- EC Name:
- Cyclododecane
- Cas Number:
- 294-62-2
- Molecular formula:
- C12H24
- IUPAC Name:
- cyclododecane
- Details on test material:
"pure" cyclododecane, no further information
Constituent 1
Results and discussion
Any other information on results incl. tables
No adverse effects on liver function were observed after oral gavage of 500 mg/kg cyclododecane.
Applicant's summary and conclusion
- Conclusions:
- Under the conditions of this study no adverse effects on liver function were observed after oral gavage of 500 mg/kg cyclododecane in rabbits.
- Executive summary:
2 rabbits were applied 500 mg/kg cyclododecane in acetone / vegetable oil by gavage. After 1 hour, 24 hours, and
7 days the following liver function tests were performed: bromothalein test (according to Hofmann-Oettel), serum glutamate pyruvate transaminase (SGPT) test and serum-sorbit-dehydrogenase (SDH) test.
Under the conditions of this study no adverse effects on liver function were observed after oral gavage of 500 mg/kg cyclododecane in rabbits.
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