Registration Dossier
Registration Dossier
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EC number: 203-951-1 | CAS number: 112-25-4
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Based on the results of an acute toxicity test with Pimephales promelas (fathead minnow ) to ethylene glycol hexyl ether (EGHE), a 96-hr LC50 of 140 mg/L was reported.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 140 mg/L
Additional information
One key study along with three supporting studies were identified for ethylene glycol hexyl ether (EGHE) acute toxicity to fish. In a 96 -hour Static Acute Fish test (identified as the key study) with fathead minnows (Pimephales promelas), conducted in accordance with OECD TG 203, EPA OTS 797.1400 and ASTM guidelines, the 96 hour LC50 value of EGHE was found to be 140 mg/L, with 95% confidence limits that ranged from 130 -140 mg/L and an NOEC value of 40 mg/L. In another 96 -hour Static Acute Fish test on fathead minnows (Pimephales promelas), conducted in accordance with the EPA and ASTM guidelines, the 96 hour LC50 value of EGHE was also reported to be 140 mg/L. Similarly, in an additional 96 -hour Static Acute Fish test on fathead minnows (Pimephales promelas), conducted in accordance with the EPA and ASTM guidelines, the 96 hour LC50 value of EGHE was found to be 139.5 mg/L. A fourth supporting study, following OECD guidelines (OECD 203) and GLPs, reported a 96 hour LC50 value for zebrafish as >100 - 220 mg/L.
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