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Description of key information

The water solubility of the chemical is reported to be 1000000 mg/L indicating high water solubility which will ensure that the chemical shall be transferred by the blood to various parts of the body. The Log Kow value of the chemical is 0.66 which according to the Lipinski rule shall ensure that the chemical shall be bio-available if ingested inside the human or animal body. The chemical has a Harmonized Classification in the acute toxicity by the oral, inhalation and the dermal route of exposure.

The chemical (3-aminopropyl)(methyl)amine is used as an intermediate for the manufacture of other chemicals. Thus, exposure by the oral route is unlikely but exposure by the dermal route is likely. There are reports that suggest that toxicity by the inhalation route is also likely. The bio-concentration factor (BCF) of the chemical (3-aminopropyl)(methyl)amine is reported to be 3.162 L/kg wet-wt (Predicted value) which suggest a low bio-accumulation potential (Bio-accumulation factor, BAF = 0.913 L/kg wet-wt).

However, in the absence of any authoritative information pertaining to the absorption, distribution, metabolism and excretion of the chemical (3-aminopropyl)(methyl)amine, bio-accumulation potential cannot be judged relying on certain physico-chemical properties and available information on BCF and BAF.

Key value for chemical safety assessment

Additional information

The water solubility of the chemical is reported to be 1000000 mg/L indicating high water solubility which will ensure that the chemical shall be transferred by the blood to various parts of the body. The Log Kow value of the chemical is 0.66 which according to the Lipinski rule shall ensure that the chemical shall be bio-available if ingested inside the human or animal body. The chemical has a Harmonized Classification in the acute toxicity by the oral, inhalation and the dermal route of exposure.

The chemical (3-aminopropyl)(methyl)amine is used as an intermediate for the manufacture of other chemicals. Thus, exposure by the oral route is unlikely but exposure by the dermal route is likely. There are reports that suggest that toxicity by the inhalation route is also likely. The bio-concentration factor (BCF) of the chemical (3-aminopropyl)(methyl)amine is reported to be 3.162 L/kg wet-wt (Predicted value) which suggest a low bio-accumulation potential (Bio-accumulation factor, BAF = 0.913 L/kg wet-wt).

However, in the absence of any authoritative information pertaining to the absorption, distribution, metabolism and excretion of the chemical (3-aminopropyl)(methyl)amine, bio-accumulation potential cannot be judged relying on certain physico-chemical properties and available information on BCF and BAF.