Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: The test substance is a gas. Exposure by the oral route is not plausible. Testing by the oral route is not scientifically sound.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1990
Report date:
1990

Materials and methods

Principles of method if other than guideline:
Male rats were administered a single dose by gavage and were observed for 14 days.
GLP compliance:
yes
Test type:
other: Approximate Lethal Dose (ALD)
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
1,1-difluoroethane
EC Number:
200-866-1
EC Name:
1,1-difluoroethane
Cas Number:
75-37-6
Molecular formula:
C2H4F2
IUPAC Name:
1,1-difluoroethane
Details on test material:
- Purity: 99.9%

Test animals

Species:
rat
Strain:
other: Crl:CD®BR
Sex:
male

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
corn oil
Doses:
200, 300, 450, 670, 1000, 1500 mg/kg
No. of animals per sex per dose:
1 male per dose
Control animals:
no

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
other: Approximate Lethal Dose (ALD)
Effect level:
> 1 500 mg/kg bw
Remarks on result:
other: Due to technical limitations, this was the maximum feasible dose tested

Applicant's summary and conclusion

Interpretation of results:
other: at worst slightly toxic
Remarks:
Criteria used for interpretation of results: expert judgment
Conclusions:
LD50 > 1500 mg/kg
Executive summary:

The test substance was administered as a single oral dose by intragastric intubation to male rats. No deaths occurred. Clinical signs of toxicity, including abdominal distension, lethargy, high carriage, wet and yellow-stained perineum, and/or diarrhoea were observed in non-lethally dosed animals. Under the conditions of this study, the ALD was >1500 mg/kg body weight. This material is considered at worst to be slightly toxic (ALD 500-5000 mg/kg) when administered as a single oral dose.