Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Exposure related observations in humans: other data

Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Documentation insufficient for assessment.

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Anesthetic properties of a series of fluorinated compounds. I. Fluorinated hydrocarbons
Author:
Van Poznak A and Artusio JF Jr.
Year:
1960
Bibliographic source:
Toxicol. Appl. Pharmacol., 2:363-373
Reference Type:
secondary source
Title:
SIDS Initial Assessment Report for SIAM 22, 1,1-Difluoroethane (HFC-152a), CAS No: 75-37-6
Author:
OECD SIDS
Year:
2006
Bibliographic source:
UNEP Publications

Materials and methods

Type of study / information:
Inhalation in humans.
Endpoint addressed:
acute toxicity: inhalation
Principles of method if other than guideline:
The test substance was inhaled briefly by several volunteers.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
1,1-difluoroethane
EC Number:
200-866-1
EC Name:
1,1-difluoroethane
Cas Number:
75-37-6
Molecular formula:
C2H4F2
IUPAC Name:
1,1-difluoroethane

Results and discussion

Results:
The test substance was inhaled briefly by several volunteers at 50000 ppm, who noted good analgesia and impending loss of consciousness.

Applicant's summary and conclusion

Executive summary:

The test substance was inhaled briefly by several volunteers at 50000 ppm, who noted good analgesia and impending loss of consciousness.