Reaction mass of decyl acrylate and octyl acrylate

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2016-10-13 to 2016-11-29

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Study performed according to GLP requirements

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

yes

Remarks:

see below

Qualifier:

equivalent or similar to guideline

Guideline:

other: OECD Guideline 123 (Partition Coefficient : Slow-Stirring Method)

Deviations:

yes

Remarks:

see below

Principles of method if other than guideline:

The OECD Guideline 105 for the Testing of Chemicals (Water solubility) is the document serving as a basis for the procedure.

However, the test item is suspected to be unstable in water that's why the definitive protocol was adapted from the flask method with slow stirring conditions described in the OECD 123 guideline.

GLP compliance:

yes (incl. QA statement)

Type of method:

other: Flask method with additional slow-stirring

Key result

Water solubility:

4.11 mg/L

Conc. based on:

test mat.

Temp.:

20 °C

pH:

4.5

Details on results:

The test concentrations reached a plateau at around 4 mg/L.
Based on OECD test guideline 105 specification, the saturation equilibrium was considered to be reached from around 24h.
Indeed, the concentrations measured in vessels did not differ by more than 15% from the time point 28.5h to the end of the test.
The water solubility of the test item was therefore calculated as the mean of the concentrations determined during this period. The value obtained was 4.11 mg/L.

The temperature monitored during the test, remained between 19.0°C and 20.0°C (mean 20.0).

pH values are reported in Table 3 (all samples were at pH 4.5).

Conclusions:

The water solubility of the test item Reaction mass of decyl acrylate and octyl acrylate was assessed using a protocol adapted from the flask method (OECD 105) with slow stirring conditions described in the OECD test guideline 123.
The water solubility of Reaction mass of decyl acrylate and octyl acrylate is 4.11 mg/L.

Executive summary:

_{The water solubility of the test item Reaction mass of decyl acrylate and octyl acrylate was assessed using a protocol adapted from the flask method (OECD 105) with slow stirring conditions described in the OECD test guideline 123.}

_{Due to the probable instability of the test item, the definitive protocol was adapted from the flask method with slow stirring conditions described in the OECD 123 guideline.}

_{The solubility of Reaction mass of decyl acrylate and octyl acrylate is 4.11 mg/L.}

_{The test was run at 20.0°C (min. 19.0°C, max. 20.0°C).}

_{Mean of pH values was 4.5.}

 

Description of key information

_{The water solubility of the test item Reaction mass of decyl acrylate and octyl acrylate was assessed using a protocol adapted from the flask method (OECD 105) with slow stirring conditions described in the OECD test guideline 123.}

_{The solubility of Reaction mass of decyl acrylate and octyl acrylate is 4.11 mg/L at 20.0°C.}

Key value for chemical safety assessment

Water solubility:

4.11 mg/L

at the temperature of:

20 °C