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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
October 1985
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1985
Report date:
1985

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
To evaluate the acute toxicity by dermal route, 4 rabbits were exposed by gavage to 4400 mg/kg bw of test substance.
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
reaction mass of decyl acrylate and octyl acrylate
EC Number:
911-295-9
Molecular formula:
C11H20O2 and C13H24O2
IUPAC Name:
reaction mass of decyl acrylate and octyl acrylate
Test material form:
liquid

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Doses:
4400 mg/kg (5 ml/kg): maximum attainable dose
No. of animals per sex per dose:
4
Control animals:
no

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD0
Effect level:
> 4 400 mg/kg bw
Remarks on result:
not determinable due to absence of adverse toxic effects
Mortality:
No mortality was observed.
Gross pathology:
No gross signs of toxicity was observed.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
Based on these results, no mortality was observed in rabbit exposed to 4400 mg/kg after acute dermal exposure.
Executive summary:

To evaluate the acute toxicity by dermal route, 4 rabbits were exposed by gavage to 4400 mg/kg bw of test substance. No mortality were observed after the administration during the study, and no sign of gross toxicity were observed at the autopsy.

In conclusion, the dermal LD0 of the test substance is higher than 4400 mg/kg bw.

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