Registration Dossier
Registration Dossier
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EC number: 911-295-9 | CAS number: -
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- October 1985
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- To evaluate the acute toxicity by dermal route, 4 rabbits were exposed by gavage to 4400 mg/kg bw of test substance.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- reaction mass of decyl acrylate and octyl acrylate
- EC Number:
- 911-295-9
- Molecular formula:
- C11H20O2 and C13H24O2
- IUPAC Name:
- reaction mass of decyl acrylate and octyl acrylate
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 4400 mg/kg (5 ml/kg): maximum attainable dose
- No. of animals per sex per dose:
- 4
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD0
- Effect level:
- > 4 400 mg/kg bw
- Remarks on result:
- not determinable due to absence of adverse toxic effects
- Mortality:
- No mortality was observed.
- Gross pathology:
- No gross signs of toxicity was observed.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Based on these results, no mortality was observed in rabbit exposed to 4400 mg/kg after acute dermal exposure.
- Executive summary:
To evaluate the acute toxicity by dermal route, 4 rabbits were exposed by gavage to 4400 mg/kg bw of test substance. No mortality were observed after the administration during the study, and no sign of gross toxicity were observed at the autopsy.
In conclusion, the dermal LD0 of the test substance is higher than 4400 mg/kg bw.
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