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Description of key information

No repeated study was available on the reaction mass of octyl and decyl acrylate. 
A read-across with C12C14 laurylacrylate for oral study is proposed.
In a subacute repeated toxicity study on Lauryl acrylate, no adverse effect was observed at the highest tests dose ( 1000 mg/kg/d).

Key value for chemical safety assessment

Repeated dose toxicity: via oral route - systemic effects

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
NOAEL
1 000 mg/kg bw/day
Study duration:
subacute
Species:
rat
Quality of whole database:
This study is considered to be reliable with a klimisch score of 1 (reliable without restrictions)

Repeated dose toxicity: inhalation - systemic effects

Endpoint conclusion
Endpoint conclusion:
no study available

Repeated dose toxicity: inhalation - local effects

Endpoint conclusion
Endpoint conclusion:
no study available

Repeated dose toxicity: dermal - systemic effects

Endpoint conclusion
Endpoint conclusion:
no study available

Repeated dose toxicity: dermal - local effects

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Combined Repeated Dose Toxicity Study with the Reproduction / Developmental Toxicity Screening Test, OECD 422 (read-across with Lauryacrylate 1214)

The objective of the study was to detect possible effects of the test substance on the integrity and performance of male and female reproductive systems including gonadal function, mating behavior, conception, gestation and parturition. Furthermore, it was intended to obtain information about the general toxicological profile including target organs and the no observed adverse effect level (NOAEL) after repeated oral administration. The duration of treatment covered a 2-week pre-mating and mating period in both sexes, approximately 1 week post-mating in males, and the entire gestation period as well as 4 days of lactation and two weeks thereafter in females.

Lauryacrylate 1214 was administered orally via gavage to groups of 10 male and 10 female Wistar rats at dose levels of 0, 100, 300 and 1000 mg/kg bw/d (respectively test groups 0,1,2 and 3).

Regarding clinical examinations, no signs of general systemic toxicity were observed in male or female parental animals of test groups 1-3 during the entire study period. Regarding clinical pathology, no treatment-related, adverse effects were observed up to a dose of the compound of 1000 mg/kg bw/d. Regarding pathology, the liver of male animals of test group 2 and 3 (300 and 1000 mg/kg bw/day, respectively) showed an increase in absolute (group 3 only) and relative weights which was regarded to be adaptive and non-adverse in the absence of histological findings.

The NOAEL (no observed adverse effect level) for general systemic toxicity was 1000 mg/kg bw/d.

Justification for classification or non-classification

Based on the results, no classification for the reaction mass of octyl and decyl acrylate is required for repeated toxicity according to the Regulation EC no. 1272/2008.