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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Two old acute studies are available on the reaction mass of octyl and decyl acrylate. No mortality was observed after a single exposure of 5000 mg/kg bw by oral route in rats, and 4400 mg/kg bw by dermal route in rabbits. No data is available by inhalation.

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
October 1985
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Qualifier:
no guideline followed
Principles of method if other than guideline:
To evaluate the acute toxicity by oral route, 6 rats were exposed by gavage to 5000 mg/kg bw of test substance.
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
yes
Species:
rat
Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Doses:
5000 mg/kg (5.7 ml/kg)
No. of animals per sex per dose:
6
Control animals:
no
Key result
Sex:
not specified
Dose descriptor:
LD0
Effect level:
> 5 000 mg/kg bw
Remarks on result:
not determinable due to absence of adverse toxic effects
Mortality:
no mortality was observed
Clinical signs:
no data
Body weight:
no data
Gross pathology:
No sign of gross toxicity was observed
Interpretation of results:
GHS criteria not met
Conclusions:
No mortality was observed after an acute exposure of 5000 mg/kg bw to 6 rats.
Executive summary:

To evaluate the acute toxicity by oral route, 6 rats were exposed by gavage to 5000 mg/kg bw of test substance. No mortality were observed after the administration during the study, and o sign of gross toxicity were observed at the autopsy.

In conclusion, the oral LD0 of the test substance is higher than 5000 mg/kg bw.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
discriminating dose
Value:
5 000 mg/kg bw
Quality of whole database:
The study is considered to be reliable with a klimish score of 2.

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Link to relevant study records
Reference
Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
October 1985
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Qualifier:
no guideline followed
Principles of method if other than guideline:
To evaluate the acute toxicity by dermal route, 4 rabbits were exposed by gavage to 4400 mg/kg bw of test substance.
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no
Species:
rabbit
Strain:
not specified
Sex:
not specified
Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Doses:
4400 mg/kg (5 ml/kg): maximum attainable dose
No. of animals per sex per dose:
4
Control animals:
no
Sex:
not specified
Dose descriptor:
LD0
Effect level:
> 4 400 mg/kg bw
Remarks on result:
not determinable due to absence of adverse toxic effects
Mortality:
No mortality was observed.
Gross pathology:
No gross signs of toxicity was observed.
Interpretation of results:
GHS criteria not met
Conclusions:
Based on these results, no mortality was observed in rabbit exposed to 4400 mg/kg after acute dermal exposure.
Executive summary:

To evaluate the acute toxicity by dermal route, 4 rabbits were exposed by gavage to 4400 mg/kg bw of test substance. No mortality were observed after the administration during the study, and no sign of gross toxicity were observed at the autopsy.

In conclusion, the dermal LD0 of the test substance is higher than 4400 mg/kg bw.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
discriminating dose
Value:
4 400 mg/kg bw
Quality of whole database:
The study is considered to be reliable with a klimish score of 2.

Additional information

Oral acute toxicity (1984)

To evaluate the acute toxicity by oral route, 6 rats were exposed by gavage to 5000 mg/kg bw of test substance. No mortality were observed after the administration during the study, and o sign of gross toxicity were observed at the autopsy.

In conclusion, the oral LD0 of the test substance is higher than 5000 mg/kg bw.

Dermal acute toxicity (1984)

To evaluate the acute toxicity by dermal route, 4 rabbits were exposed by gavage to 4400 mg/kg bw of test substance. No mortality were observed after the administration during the study, and no sign of gross toxicity were observed at the autopsy.

In conclusion, the dermal LD0 of the test substance is higher than 4400 mg/kg bw.

Justification for classification or non-classification

Based on the available data on the reaction mass of octyl and decyl acrylate, no classification is required for acute toxicity according to the Regulation EC no. 1272/2008.