Registration Dossier
Registration Dossier
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EC number: 205-532-9 | CAS number: 142-29-0
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: comparable to guideline study with acceptable restrictions; only 4 male animals per dose were used; Regarding the occlusive dressing the test protocol used was harsher; no necropsy performed
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Range finding toxicity data: List VI
- Author:
- Smyth H.F. et al.
- Year:
- 1 962
- Bibliographic source:
- J. Amer. Ind. Hyg. Assoc. J. 23: 95
- Reference Type:
- publication
- Title:
- Range finding toxicity data: List VII
- Author:
- Smyth H.F. et al.
- Year:
- 1 969
- Bibliographic source:
- J. Amer. Ind. Hyg. Assoc. J. 30: 470
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- only 4 male animals per dose were used; occlusive dressing; no necropsy performed
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- Cyclopentene
- EC Number:
- 205-532-9
- EC Name:
- Cyclopentene
- Cas Number:
- 142-29-0
- Molecular formula:
- C5H8
- IUPAC Name:
- cyclopentene
- Details on test material:
- no further data available
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- - Weight at study initiation: 2.5 - 3.5 kg
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Duration of exposure:
- 24 hours
- Doses:
- As no information about the number of administered dose levels is given, the total amount of animals could not be determined.
- No. of animals per sex per dose:
- 4
- Control animals:
- no
- Details on study design:
- The animals were immobilized during the contact period; 14 days post-exposure observation period.
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 231 mg/kg bw
Any other information on results incl. tables
Value of LD50 given in the literature was 1.59 ml/kg. With respect to the density of cyclopentene (0.774 g/ml), the value in mg/ml refers to 1231 mg/kg.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
