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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: comparable to guideline study with acceptable restrictions; only 4 male animals per dose were used; Regarding the occlusive dressing the test protocol used was harsher; no necropsy performed

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Range finding toxicity data: List VI
Author:
Smyth H.F. et al.
Year:
1962
Bibliographic source:
J. Amer. Ind. Hyg. Assoc. J. 23: 95
Reference Type:
publication
Title:
Range finding toxicity data: List VII
Author:
Smyth H.F. et al.
Year:
1969
Bibliographic source:
J. Amer. Ind. Hyg. Assoc. J. 30: 470

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Deviations:
yes
Remarks:
only 4 male animals per dose were used; occlusive dressing; no necropsy performed
GLP compliance:
no
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
Cyclopentene
EC Number:
205-532-9
EC Name:
Cyclopentene
Cas Number:
142-29-0
Molecular formula:
C5H8
IUPAC Name:
cyclopentene
Details on test material:
no further data available

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male
Details on test animals or test system and environmental conditions:
- Weight at study initiation: 2.5 - 3.5 kg

Administration / exposure

Type of coverage:
occlusive
Vehicle:
not specified
Duration of exposure:
24 hours
Doses:
As no information about the number of administered dose levels is given, the total amount of animals could not be determined.
No. of animals per sex per dose:
4
Control animals:
no
Details on study design:
The animals were immobilized during the contact period; 14 days post-exposure observation period.

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
1 231 mg/kg bw

Any other information on results incl. tables

Value of LD50 given in the literature was 1.59 ml/kg. With respect to the density of cyclopentene (0.774 g/ml), the value in mg/ml refers to 1231 mg/kg.

Applicant's summary and conclusion