Registration Dossier
Registration Dossier
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EC number: 205-532-9 | CAS number: 142-29-0
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: comparable to guideline study with acceptable restrictions; No post-exposure observation time, no necropsy performed.
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute, Subacute and Subchronic Inhalation Toxicity of Cyclopentene
- Author:
- Kimmerle G., Thyssen J.
- Year:
- 1 975
- Bibliographic source:
- Int. Arch. Arbeitsmed. 34, 177-184
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- yes
- Remarks:
- no post-exposure observation time, no necropsy performed
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Cyclopentene
- EC Number:
- 205-532-9
- EC Name:
- Cyclopentene
- Cas Number:
- 142-29-0
- Molecular formula:
- C5H8
- IUPAC Name:
- cyclopentene
- Details on test material:
- - Analytical purity: 99.8 % (technical)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 140-150 g
- Fasting period before study:
- Housing: in groups of 5 in cages
- Diet (e.g. ad libitum): ad libitum ( Altromin standard diet)
- Water (e.g. ad libitum): ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20°C +/-2°C
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: no data
- Duration of exposure:
- 4 h
- Concentrations:
- 5,8; 11,3; 16,9; 22,9 mg/l
(original dose levels: 2040, 4015, 5980 and 8110 ppm/ 4h.) - No. of animals per sex per dose:
- 80
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 22.9 mg/L air
- Exp. duration:
- 4 h
- Remarks on result:
- other: vapour
- Mortality:
- No death occured.
- Clinical signs:
- other: After a 4-hr exposure to cyclopentene concentrations of 11,3 mg/l or less animals showed no toxic symptoms.
- Other findings:
- The animals (males and females) exposed to higher concentrations developed symptoms which consisted of irritation of the mucosa of the upper
airways
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
