Registration Dossier
Registration Dossier
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EC number: 205-532-9 | CAS number: 142-29-0
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions; no necropsy performed; no data about doses used; no mortality data available.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Range finding toxicity data: List VI.
- Author:
- Smyth H.F. et al.:
- Year:
- 1 962
- Bibliographic source:
- J. Amer. Ind. Hyg. Assoc. J. 23: 95
- Reference Type:
- publication
- Title:
- Range finding toxicity data: List VII.
- Author:
- Smyth H.F. et al.
- Year:
- 1 969
- Bibliographic source:
- J. Amer. Ind. Hyg. Assoc. J. 30: 470
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Method is described in the publication of Smyth et al (cf. Reference)
Gastric intubation of groups of 5 non-fasted male Carworth-Wistar rats (age: 4-5 weeks; bw: 90-120 g). The dosages were arranged in a logarithmic series differing by a factor of two. 14 days post-exposure observation period. No further details. - GLP compliance:
- not specified
- Test type:
- other: Smyth and Carpenter (see reference)
Test material
- Reference substance name:
- Cyclopentene
- EC Number:
- 205-532-9
- EC Name:
- Cyclopentene
- Cas Number:
- 142-29-0
- Molecular formula:
- C5H8
- IUPAC Name:
- cyclopentene
- Details on test material:
- no further data available
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Doses:
- 1656.0 mg/kg bw (Original value 2.14 ml/kg (density cyclopentene 0.774 g/ml);
As no information about the number of administered dose levels is given, the total amount of animals could not be determined. - No. of animals per sex per dose:
- 5
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 656 mg/kg bw
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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