Registration Dossier
Registration Dossier
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EC number: 205-532-9 | CAS number: 142-29-0
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
Materials and methods
- Principles of method if other than guideline:
- BASF test:
The test substance was applied to the eyes of rabbits. The readings were performed using a BASF scheme which is convertable into the Draize system (s Details on study design). - GLP compliance:
- no
Test material
- Reference substance name:
- Cyclohexene
- EC Number:
- 203-807-8
- EC Name:
- Cyclohexene
- Cas Number:
- 110-83-8
- Molecular formula:
- C6H10
- IUPAC Name:
- cyclohexene
Constituent 1
Test animals / tissue source
- Species:
- rabbit
Test system
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.05 ml - Observation period (in vivo):
- 8 days
- Number of animals or in vitro replicates:
- 2
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): no washing done
SCORING SYSTEM:
BASF scheme
cornea score (Tr):
+ corresponds to Draize score 1
+-++ corresponds to Draize score 2
++ corresponds to Draize score 3
+++ corresponds to Draize score 4
iris score:
ciliare injection corresponds to Draize score 1
iritis corresponds to Draize score 2
conjuntivae score
R+ corresponds to Draize score 1
R++ corresponds to Draize score 2
R+++ corresponds to Draize score 3
chemosis score
Ö (+) corresponds to Draize score 1
Ö+ corresponds to Draize score 2
Ö++ corresponds to Draize score 3
Ö+++ corresponds to Draize score 3-4
Readings were performed 24, 48 and 72 hours and 6 and 7 days after the application.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24, 48 nd 72 hours
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- other: not applicable
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 1
- Max. score:
- 3
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicalbe
Any other information on results incl. tables
|
Animal 1 |
Animal 2 |
||||||
|
Corn. |
Iris |
Conj. |
Chem. |
Corn. |
Iris |
Conj. |
Chem. |
24 h |
0 |
0 |
1 |
0 |
0 |
0 |
1 |
0 |
48 h |
0 |
0 |
1 |
0 |
0 |
0 |
1 |
0 |
72 h |
0 |
0 |
1 |
0 |
0 |
0 |
1 |
0 |
7 d |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
Mean 24, 48 and 72 h |
0 |
0 |
0 |
1 |
0 |
0 |
1 |
0 |
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
