Registration Dossier
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EC number: 701-042-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
The skin sensitisation potential of the Fatty Acid Polyol with CAS No. 57675-44-2 (2-ethyl-2-[[(1-oxooleyl)oxy]methyl]-1,3-propanediyl dioleate) was evaluated in guinea pigs with a Buehler test for skin sensitisation (Key, Cognis, Pittermann, 1994, Skin sensitization, RL2). 20 female Pirbright white; Hsd/Win:DH guinea pigs were treated with the test substance and compared with 10 control animals. Three epidermal inductions were performed with 100 % test substance in weekly intervals for 6 hours under occlusive conditions (cranial shared flank). 14 days after the last induction treatment, the shorn flanks (caudal) of all animals were challenged for 6 hours epicutaneously with 100% test substance (diluted in peanut oil) under occlusive conditions. Animals were evaluated for skin reactions 24, 48 and 72 h after challenge. Slight dermal effects on the right flank were seen in one animal of the test group and one animal of the control group. Effects were reversible within 72 h (control group) or were still apparent at the end of the observation period (72 h).
According to the OASIS Database provided from the Danish Environmental Protection Agency and Danish QSAR group, National Food Institute, Technical University of Denmark (DTU) the CAS No. 57675-44-2 (2-ethyl-2-[[(1-oxooleyl)oxy]methyl]-1,3-propanediyl dioleate) was predicted to have no skin sensitisation potential (Danish EPA, QSAR prediction skin sensitisation, 2010, RL2).
Migrated from Short description of key information:
Key, Cognis, Pittermann, 1994, Skin sensitization, RL2 – not sensitising
Danish EPA, QSAR prediction skin sensitisation, 2010, RL2 – not sensitising
Respiratory sensitisation
Endpoint conclusion
- Additional information:
- Migrated from Short description of key information:
No data on respiratory sensitisation was available.
Justification for classification or non-classification
According to the DSD and CLP criteria for classification and labelling of dangerous substances CAS No. 57675-44-2 (2-ethyl-2-[[(1-oxooleyl)oxy]methyl]-1,3-propanediyl dioleate) is not classified as sensitising.
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