Fatty acids, C18-unsatd., diesters and triesters with trimethylolpropane

Basic toxicokinetics

Administrative data

Endpoint:

basic toxicokinetics

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

other information

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Only secondary data Short review on metabolism from previous publications.

Data source

Reference

Reference Type:

publication

Title:

Lack of toxicity by medium chain triglycerides (MCT) in canines during a 90-day feeding study

Author:

Matulka, R.

Year:

2009

Bibliographic source:

Food and Chemical Toxicology 47; 35–39.

Materials and methods

Objective of study:

metabolism

Test material

Test material information

Constituent 1

Reference substance name:

medium chain triglycerides

IUPAC Name:

medium chain triglycerides

Results and discussion

Any other information on results incl. tables

The metabolism of Medium chain triglycerides in the canine is a process whereby lipases from the buccal cavity and pancreas release the fatty acids in the gastrointestinal tract where they are absorbed. Unlike long chain triglycerides (LCT), where long chain fatty acids (LCFA) form micelles and are absorbed via the thoracic lymph duct, MCFA are most often transported directly to the liver through the portal vein and do not necessarily form micelles. Also, MCFA do not re-esterify into MCT across the intestinal mucosa. MCFA are transported into the hepatocytes through a carnitine-independent mechanism, and are metabolized into carbon dioxide, acetate, and ketones through b-oxidation and the citric acid cycle.