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Toxicological information

Genetic toxicity: in vitro

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Administrative data

Endpoint:
in vitro gene mutation study in bacteria
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
WHO Food Additive Series 35: 4-Hexylresorcinol (136-77-6)
Year:
1983
Bibliographic source:
http://www.inchem.org/documents/jecfa/jecmono/v35je04.htm

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
no guideline provided
GLP compliance:
not specified
Type of assay:
bacterial reverse mutation assay

Test material

Constituent 1
Chemical structure
Reference substance name:
4-hexylresorcinol
EC Number:
205-257-4
EC Name:
4-hexylresorcinol
Cas Number:
136-77-6
Molecular formula:
C12H18O2
IUPAC Name:
4-hexylresorcinol

Method

Species / strain
Species / strain / cell type:
S. typhimurium, other: TA98, TA100, TA1535, TA1537, TA1538
Metabolic activation:
with and without
Test concentrations with justification for top dose:
0-30 µg/plate

Results and discussion

Test results
Species / strain:
S. typhimurium, other: TA98, TA100, TA1535, TA1537, TA1538
Metabolic activation:
with and without
Genotoxicity:
negative
Cytotoxicity / choice of top concentrations:
not specified

Applicant's summary and conclusion