Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
eye irritation: in vitro / ex vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Toxicology of the Eye. 2nd ed. Springfield, Illinois: Charles C. Thomas, 1974., p. 548
Author:
Grant, W. M.
Year:
1974
Bibliographic source:
Toxnet

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
no guideline provided
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
4-hexylresorcinol
EC Number:
205-257-4
EC Name:
4-hexylresorcinol
Cas Number:
136-77-6
Molecular formula:
C12H18O2
IUPAC Name:
4-hexylresorcinol

Test animals / tissue source

Species:
rabbit

Test system

Amount / concentration applied:
1:10000, 1:1000
Duration of treatment / exposure:
5 min

Results and discussion

In vitro

Results
Irritation parameter:
other: no score recorded
Remarks on result:
positive indication of irritation
Other effects / acceptance of results:
Tests on rabbit eyes have shown that surface of cornea can be irrigated for 5 min with 1:10,000 solution without injury, but that irrigationwith 1:1,000 solution for 1-5 min caused diffuse edema of epithelium, followed in 2 or 3 hr by bluish stromal edema and hyperemia of iris.

Applicant's summary and conclusion

Interpretation of results:
Category 2 (irritating to eyes) based on GHS criteria