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EC number: 209-886-5 | CAS number: 596-49-6
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
Estimation Programs Interface Suite (EPI suite, 2016) was run to predict the biodegradation potential of the test compound Benzenemethanol, 4-(diethylamino)-alpha,alpha-bis(4-(diethylamino)phenyl)- (CAS no. 596 -49 -6) in the presence of mixed populations of environmental microorganisms. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI LInear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that Benzenemethanol, 4-(diethylamino)-alpha, alpha-bis (4-(diethylamino ) phenyl)- is not expected to be readily biodegradable.
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
Additional information
Predicted data for the test compoundBenzenemethanol, 4-(diethylamino)-alpha,alpha-bis(4-(diethylamino)phenyl)-(CAS No. 596-49-6) and the study for its read across substance were reviewed for the biodegradation end point which are summarized as below:
Estimation Programs Interface Suite (EPI suite, 2016) was run to predict the biodegradation potential of the test compound Benzenemethanol, 4-(diethylamino)-alpha,alpha-bis(4-(diethylamino)phenyl)- (CAS no. 596 -49 -6) in the presence of mixed populations of environmental microorganisms. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI LInear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that Benzenemethanol, 4-(diethylamino)-alpha, alpha-bis (4-(diethylamino ) phenyl)- is not expected to be readily biodegradable.
28-days Manometric respirometry test following the OECD guideline 301F to determine the ready biodegradability of the read across chemical Hydrogen [4-[4-(diethylamino)-2', 4'-disulphonatobenzhydrylidene] cyclohexa-2, 5-dien-1-ylidene] diethylammonium, sodium salt (CAS No. 129-17-9) (UERL study report, Sustainability Support Services (Europe) AB, Report no.129-17-9/02/2015/RBD, 2016). The test system included control, test item and reference item. The concentration of read across chemical and reference item (Sodium Benzoate) chosen for both the study was 100mg/L, while that of inoculum was 10ml/l. ThOD (Theoretical oxygen demand) of test and reference item was determined by calculation. % Degradation was calculated using the values of BOD and ThOD for read across substance and reference item.
The BOD28value of Hydrogen [4-[4-(diethylamino)-2', 4'-disulphonatobenzhydrylidene] cyclohexa-2, 5-dien-1-ylidene] diethylammonium, sodium salt (CAS No. 129-17-9) was observed to be 0.0335 mgO2/mg. ThOD was calculated as 1.892 mgO2/mg. Accordingly, the % degradation of read across substance after 28 days of incubation at 20 ± 1°C according to manometric respirometry test was determined to be 1.77%.Based on the results, Hydrogen [4-[4-(diethylamino)-2', 4'-disulphonatobenzhydrylidene] cyclohexa-2, 5-dien-1-ylidene] diethylammonium, sodium salt, under the test conditions, was determined to be non-biodegradable at 20 ± 1°C over a period of 28 days.
Biodegradation study was conducted for 28 days for evaluating the percentage biodegradability of read across substance CI acid violet 49 (CAS no. 1694-09-3) (J-CHECK, 2016). Concentration of inoculum i.e, sludge used was 30 mg/l and initial substance conc. used in the study was 100 mg/l. The percentage degradation of read across substance CI acid violet 49 was determined to be 1% by BOD, 4% by TOC removal and 0% by HPLC in 28 days. Thus, the substance CI acid violet 49 is not expected to be readily biodegradable in water.
On the basis of above results for target and read across substance, it can be concluded that the test substance Benzenemethanol, 4-(diethylamino)- alpha,alpha-bis(4-(diethylamino)phenyl)- can be expected to be not readily biodegradable in nature.
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