p,p',p''-tris(diethylamino)trityl alcohol

Endpoint summary

Description of key information

Skin Irritation:

The skin irritation potential for Benzenemethanol, 4-(diethylamino)-alpha,alpha-bis(4-(diethylamino)phenyl)- (CAS No: 596-49-6)is estimated using OECD QSAR toolbox version 3.4 The test substance Benzenemethanol, 4-(diethylamino)-alpha,alpha-bis(4-(diethylamino)phenyl)- (CAS No: 596-49-6)is estimated to be not irritating to skin of New Zealand White rabbits.

Eye Irritation:  

The ocular irritation potential of Benzenemethanol, 4-(diethylamino)- alpha, alpha -bis 4-(diethylamino)phenyl - was estimated using OECD QSAR toolbox v3.4

Benzenemethanol, 4-(diethylamino)- alpha, alpha -bis 4-(diethylamino)phenyl - was estimated to be not irritating to rabbit eyes.

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records

Reference

Endpoint:

skin irritation: in vivo

Type of information:

(Q)SAR

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification

Justification for type of information:

The supporting QMRF report has been attached

Qualifier:

according to guideline

Guideline:

other: Prediction is done using QSAR Toolbox version 3.4

Principles of method if other than guideline:

Prediction is done using QSAR Toolbox version 3.4

GLP compliance:

no

Specific details on test material used for the study:

Name of test material (as cited in study report): Benzenemethanol, 4-(diethylamino)- alpha, alpha -bis 4-(diethylamino)phenyl -
-Molecular formula: C31H43N3O1
Molecular weight: 473.71g/mol
Smiles notation: OC(c(ccc(N(CC)CC)c1)c1)(c(ccc(N(CC)CC)c2)c2)c(ccc(N(CC)CC)c3)c3
Substance type: Organic
Physical State: Solid

Species:

rabbit

Strain:

New Zealand White

Details on test animals or test system and environmental conditions:

no data

Type of coverage:

occlusive

Preparation of test site:

clipped

Vehicle:

water

Controls:

not specified

Amount / concentration applied:

no data

Duration of treatment / exposure:

4 hours

Observation period:

72 hours

Number of animals:

3 male rabbits

Details on study design:

no data

Irritation parameter:

overall irritation score

Basis:

mean

Time point:

72 h

Reversibility:

no data

Remarks on result:

no indication of irritation

Irritant / corrosive response data:

no irritation was observed on test rabbits.

Estimation method: Takes mode value from the 5 nearest neighbours
Domain  logical expression:Result: In Domain

(((((("a" or "b" or "c" or "d") and("e" and(not "f")) ) and("g" and(not "h")) ) and("i" and(not "j")) ) and("k" and(not "l")) ) and("m" and "n") )

Domain logical expression index: "a"

Referential boundary:The target chemical should be classified as Aliphatic Carbon [CH] AND Aliphatic Carbon [-CH2-] AND Aliphatic Carbon [-CH3] AND Aliphatic Nitrogen, one aromatic attach [-N] AND Amino, aliphatic attach [-N<] AND Aromatic Carbon [C] AND Olefinic carbon [=CH- or =C<] by Organic functional groups (US EPA)

Domain logical expression index: "b"

Referential boundary:The target chemical should be classified as Amine AND Anion AND Aromatic compound AND Cation AND Tertiary amine AND Tertiary mixed amine by Organic functional groups, Norbert Haider (checkmol)

Domain logical expression index: "c"

Referential boundary:The target chemical should be classified as Alkene AND Ammonium salt AND Aromatic amine AND Aryl by Organic Functional groups

Domain logical expression index: "d"

Referential boundary:The target chemical should be classified as Alkene AND Ammonium salt AND Aromatic amine AND Overlapping groups by Organic Functional groups (nested)

Domain logical expression index: "e"

Referential boundary:The target chemical should be classified as No alert found by DNA binding by OASIS v.1.4

Domain logical expression index: "f"

Referential boundary:The target chemical should be classified as AN2 OR AN2 >>  Michael-type addition, quinoid structures OR AN2 >>  Michael-type addition, quinoid structures >> Quinoneimines OR AN2 >>  Michael-type addition, quinoid structures >> Quinones and Trihydroxybenzenes OR AN2 >> Nucleophilic addition reaction with cycloisomerization OR AN2 >> Nucleophilic addition reaction with cycloisomerization >> Hydrazine Derivatives OR AN2 >> Schiff base formation by aldehyde formed after metabolic activation OR AN2 >> Schiff base formation by aldehyde formed after metabolic activation >> Geminal Polyhaloalkane Derivatives OR AN2 >> Shiff base formation after aldehyde release OR AN2 >> Shiff base formation after aldehyde release >> Specific Acetate Esters OR Non-covalent interaction OR Non-covalent interaction >> DNA intercalation OR Non-covalent interaction >> DNA intercalation >> Amino Anthraquinones OR Non-covalent interaction >> DNA intercalation >> DNA Intercalators with Carboxamide and Aminoalkylamine Side Chain OR Non-covalent interaction >> DNA intercalation >> Fused-Ring Primary Aromatic Amines OR Non-covalent interaction >> DNA intercalation >> Quinones and Trihydroxybenzenes OR Radical OR Radical >> Generation of ROS by glutathione depletion (indirect) OR Radical >> Generation of ROS by glutathione depletion (indirect) >> Haloalkanes Containing Heteroatom OR Radical >> Radical mechanism via ROS formation (indirect) OR Radical >> Radical mechanism via ROS formation (indirect) >> Amino Anthraquinones OR Radical >> Radical mechanism via ROS formation (indirect) >> Fused-Ring Primary Aromatic Amines OR Radical >> Radical mechanism via ROS formation (indirect) >> Geminal Polyhaloalkane Derivatives OR Radical >> Radical mechanism via ROS formation (indirect) >> Hydrazine Derivatives OR Radical >> Radical mechanism via ROS formation (indirect) >> Nitroaniline Derivatives OR Radical >> Radical mechanism via ROS formation (indirect) >> Nitroarenes with Other Active Groups OR Radical >> Radical mechanism via ROS formation (indirect) >> Nitrophenols, Nitrophenyl Ethers and Nitrobenzoic Acids OR Radical >> Radical mechanism via ROS formation (indirect) >> Quinones and Trihydroxybenzenes OR Radical >> Radical mechanism via ROS formation (indirect) >> Single-Ring Substituted Primary Aromatic Amines OR Radical >> ROS formation after GSH depletion (indirect) OR Radical >> ROS formation after GSH depletion (indirect) >> Quinoneimines OR SN1 OR SN1 >> Nucleophilic attack after carbenium ion formation OR SN1 >> Nucleophilic attack after carbenium ion formation >> Specific Acetate Esters OR SN1 >> Nucleophilic attack after diazonium or carbenium ion formation OR SN1 >> Nucleophilic attack after diazonium or carbenium ion formation >> Nitroarenes with Other Active Groups OR SN1 >> Nucleophilic attack after metabolic nitrenium ion formation OR SN1 >> Nucleophilic attack after metabolic nitrenium ion formation >> Amino Anthraquinones OR SN1 >> Nucleophilic attack after metabolic nitrenium ion formation >> Fused-Ring Primary Aromatic Amines OR SN1 >> Nucleophilic attack after nitrenium ion formation OR SN1 >> Nucleophilic attack after nitrenium ion formation >> Single-Ring Substituted Primary Aromatic Amines OR SN1 >> Nucleophilic attack after reduction and nitrenium ion formation OR SN1 >> Nucleophilic attack after reduction and nitrenium ion formation >> Nitroaniline Derivatives OR SN1 >> Nucleophilic attack after reduction and nitrenium ion formation >> Nitroarenes with Other Active Groups OR SN1 >> Nucleophilic attack after reduction and nitrenium ion formation >> Nitrophenols, Nitrophenyl Ethers and Nitrobenzoic Acids OR SN2 OR SN2 >> Acylation OR SN2 >> Acylation >> Specific Acetate Esters OR SN2 >> Acylation involving a leaving group after metabolic activation OR SN2 >> Acylation involving a leaving group after metabolic activation >> Geminal Polyhaloalkane Derivatives OR SN2 >> Alkylation, direct acting epoxides and related after cyclization OR SN2 >> Alkylation, direct acting epoxides and related after cyclization >> Nitrogen and Sulfur Mustards OR SN2 >> Alkylation, nucleophilic substitution at sp3-carbon atom OR SN2 >> Alkylation, nucleophilic substitution at sp3-carbon atom >> Haloalkanes Containing Heteroatom OR SN2 >> Direct nucleophilic attack on diazonium cation OR SN2 >> Direct nucleophilic attack on diazonium cation >> Hydrazine Derivatives OR SN2 >> Nucleophilic substitution at sp3 Carbon atom OR SN2 >> Nucleophilic substitution at sp3 Carbon atom >> Haloalkanes Containing Heteroatom OR SN2 >> Nucleophilic substitution at sp3 Carbon atom >> Specific Acetate Esters OR SN2 >> Nucleophilic substitution at sp3 carbon atom after thiol (glutathione) conjugation OR SN2 >> Nucleophilic substitution at sp3 carbon atom after thiol (glutathione) conjugation >> Geminal Polyhaloalkane Derivatives OR SN2 >> SN2 attack on activated carbon Csp3 or Csp2 OR SN2 >> SN2 attack on activated carbon Csp3 or Csp2 >> Nitroarenes with Other Active Groups by DNA binding by OASIS v.1.4

Domain logical expression index: "g"

Referential boundary:The target chemical should be classified as Non binder, without OH or NH2 group by Estrogen Receptor Binding

Domain logical expression index: "h"

Referential boundary:The target chemical should be classified as Non binder, impaired OH or NH2 group OR Non binder, MW>500 OR Non binder, non cyclic structure OR Strong binder, NH2 group OR Strong binder, OH group OR Weak binder, OH group by Estrogen Receptor Binding

Domain logical expression index: "i"

Referential boundary:The target chemical should be classified as No alert found by Protein binding by OECD

Domain logical expression index: "j"

Referential boundary:The target chemical should be classified as Acylation OR Acylation >> Direct Acylation Involving a Leaving group OR Acylation >> Direct Acylation Involving a Leaving group >> Acetates OR SN2 OR SN2 >> SN2 reaction at sp3 carbon atom OR SN2 >> SN2 reaction at sp3 carbon atom >> Alkyl diazo by Protein binding by OECD

Domain logical expression index: "k"

Referential boundary:The target chemical should be classified as AN2 AND AN2 >> Michael addition to the quinoid type structures AND AN2 >> Michael addition to the quinoid type structures >> N-Subsituted Aromatic Amines by Protein binding alerts for Chromosomal aberration by OASIS v.1.2

Domain logical expression index: "l"

Referential boundary:The target chemical should be classified as No alert found by Protein binding alerts for Chromosomal aberration by OASIS v.1.2

Domain logical expression index: "m"

Parametric boundary:The target chemical should have a value of log Kow which is >= 3.28

Domain logical expression index: "n"

Parametric boundary:The target chemical should have a value of log Kow which is <= 7.21

Interpretation of results:

not irritating

Conclusions:

The substance Benzenemethanol, 4-(diethylamino)-alpha,alpha-bis(4-(diethylamino)phenyl)- (CAS No: 596-49-6) is estimated to be not irritating to skin of New Zealand White rabbits.

Executive summary:

The skin irritation potential for Benzenemethanol, 4-(diethylamino)-alpha,alpha-bis(4-(diethylamino)phenyl)- (CAS No: 596-49-6)is estimated using OECD QSAR toolbox version 3.4 The test substance Benzenemethanol, 4-(diethylamino)-alpha,alpha-bis(4-(diethylamino)phenyl)- (CAS No: 596-49-6)is estimated to be not irritating to skin of New Zealand White rabbits.

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed (not irritating)

Eye irritation

Link to relevant study records

Reference

Endpoint:

eye irritation: in vivo

Type of information:

(Q)SAR

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification

Justification for type of information:

The supporting QMRF report has been attached

Qualifier:

according to guideline

Guideline:

other: Prediction was done using OECD QSAR toolbox v3.4

Principles of method if other than guideline:

Prediction was done using OECD QSAR toolbox v3.4

GLP compliance:

no

Specific details on test material used for the study:

Name of test material (as cited in study report): Benzenemethanol, 4-(diethylamino)- alpha, alpha -bis 4-(diethylamino)phenyl -
-Molecular formula:C31H43N3O
Molecular weight: 473.71g/mol
Smiles notation: OC(c(ccc(N(CC)CC)c1)c1)(c(ccc(N(CC)CC)c2)c2)c(ccc(N(CC)CC)c3)c3
Substance type: Organic
Physical State: Solid

Species:

rabbit

Strain:

not specified

Details on test animals or tissues and environmental conditions:

not specified

Vehicle:

unchanged (no vehicle)

Controls:

not specified

Amount / concentration applied:

0.1 ml

Duration of treatment / exposure:

not specified

Observation period (in vivo):

96 Hours

Duration of post- treatment incubation (in vitro):

not specified

Number of animals or in vitro replicates:

not specified

Details on study design:

not specified

Irritation parameter:

overall irritation score

Basis:

mean

Time point:

other: 96 h

Score:

0

Reversibility:

not specified

Remarks on result:

no indication of irritation

Irritant / corrosive response data:

No irritation was observed

Estimation method: Takes mode value from the 8 nearest neighbours
Domain  logical expression:Result: In Domain

(((((("a" or "b" or "c" or "d") and("e" and(not "f")) ) and("g" and(not "h")) ) and("i" and(not "j")) ) and("k" and(not "l")) ) and("m" and "n") )

Domain logical expression index: "a"

Referential boundary:The target chemical should be classified as Aliphatic Carbon [CH] AND Aliphatic Carbon [-CH2-] AND Aliphatic Carbon [-CH3] AND Aliphatic Nitrogen, one aromatic attach [-N] AND Amino, aliphatic attach [-N<] AND Aromatic Carbon [C] AND Olefinic carbon [=CH- or =C<] by Organic functional groups (US EPA)

Domain logical expression index: "b"

Referential boundary:The target chemical should be classified as Amine AND Anion AND Aromatic compound AND Cation AND Tertiary amine AND Tertiary mixed amine by Organic functional groups, Norbert Haider (checkmol)

Domain logical expression index: "c"

Referential boundary:The target chemical should be classified as Alkene AND Ammonium salt AND Aromatic amine AND Aryl by Organic Functional groups

Domain logical expression index: "d"

Referential boundary:The target chemical should be classified as Alkene AND Ammonium salt AND Aromatic amine AND Overlapping groups by Organic Functional groups (nested)

Domain logical expression index: "e"

Referential boundary:The target chemical should be classified as (!Undefined)Group All Lipid Solubility < 0.01 g/kg AND (!Undefined)Group CN Lipid Solubility < 0.4 g/kg AND Group All Melting Point > 200 C AND Group CN Aqueous Solubility < 0.1 g/L AND Group CN Melting Point > 180 C AND Group CN Molecular Weight > 290 g/mol AND Group CN Vapour Pressure < 0.001 Pa by Skin irritation/corrosion Exclusion rules by BfR

Domain logical expression index: "f"

Referential boundary:The target chemical should be classified as (!Undefined)Group All log Kow < -3.1 OR (!Undefined)Group All log Kow > 9 OR (!Undefined)Group All Melting Point > 200 C OR (!Undefined)Group CNHal Lipid Solubility < 4 g/kg OR (!Undefined)Group CNHal Lipid Solubility < 400 g/kg OR (!Undefined)Group CNS Surface Tension > 62 mN/m OR Exclusion rules not met OR Group All log Kow < -3.1 OR Group All log Kow > 9 OR Group C Aqueous Solubility < 0.0001 g/L OR Group C Melting Point > 55 C OR Group C Molecular Weight > 350 g/mol OR Group C Vapour Pressure < 0.0001 Pa OR Group CN Aqueous Solubility < 0.0001 g/L OR Group CN log Kow > 4.5 OR Group CN log Kow > 5.5 OR Group CN Molecular Weight > 540 g/mol OR Group CNHal Aqueous Solubility < 0.001 g/L OR Group CNHal Aqueous Solubility < 0.1 g/L OR Group CNHal log Kow > 3.8 OR Group CNHal Molecular Weight > 370 g/mol OR Group CNHal Molecular Weight > 380 g/mol OR Group CNS log Kow < 0.5 OR Group CNS Melting Point > 120 C OR Group CNS Melting Point > 50 C OR Group CNS Molecular Weight > 620 g/mol by Skin irritation/corrosion Exclusion rules by BfR

Domain logical expression index: "g"

Referential boundary:The target chemical should be classified as No alert found by Protein binding alerts for skin sensitization by OASIS v1.4

Domain logical expression index: "h"

Referential boundary:The target chemical should be classified as Acylation OR Acylation >> Ester aminolysis OR Acylation >> Ester aminolysis >> Amides OR Nucleophilic addition OR Nucleophilic addition >> Addition to carbon-hetero double bonds OR Nucleophilic addition >> Addition to carbon-hetero double bonds >> Ketones OR Schiff base formation OR Schiff base formation >> Pyrazolones and Pyrazolidinones derivatives OR Schiff base formation >> Pyrazolones and Pyrazolidinones derivatives >> Pyrazolones and Pyrazolidinones  OR SN1 OR SN1 >> Carbenium ion formation (enzymatic) OR SN1 >> Carbenium ion formation (enzymatic) >> Carbenium ion OR SNAr OR SNAr >> Nucleophilic aromatic substitution on activated aryl and heteroaryl compounds OR SNAr >> Nucleophilic aromatic substitution on activated aryl and heteroaryl compounds >> Activated aryl and heteroaryl compounds by Protein binding alerts for skin sensitization by OASIS v1.4

Domain logical expression index: "i"

Referential boundary:The target chemical should be classified as Aromatic Amine Type Compounds by Oncologic Primary Classification

Domain logical expression index: "j"

Referential boundary:The target chemical should be classified as Acyl and Benzoyl Type Compounds OR Alpha-Haloalkylamine Reactive Functional Groups OR Carbamyl Halide Type Compounds OR Halogenated Aromatic Hydrocarbon Type Compounds OR Not classified OR Phenol Type Compounds OR Urea Type Compounds by Oncologic Primary Classification

Domain logical expression index: "k"

Referential boundary:The target chemical should be classified as No alert found by Protein binding by OECD

Domain logical expression index: "l"

Referential boundary:The target chemical should be classified as Acylation OR Acylation >> Direct Acylation Involving a Leaving group OR Acylation >> Direct Acylation Involving a Leaving group >> Acetates OR SN2 OR SN2 >> SN2 reaction at sp3 carbon atom OR SN2 >> SN2 reaction at sp3 carbon atom >> Alkyl diazo by Protein binding by OECD

Domain logical expression index: "m"

Parametric boundary:The target chemical should have a value of log Kow which is >= 1.79

Domain logical expression index: "n"

Parametric boundary:The target chemical should have a value of log Kow which is <= 7.75

Interpretation of results:

other: not irritating

Conclusions:

Benzenemethanol, 4-(diethylamino)- alpha, alpha -bis 4-(diethylamino)phenyl - was estimated to be not irritating to rabbit eyes.

Executive summary:

The ocular irritation potential of Benzenemethanol, 4-(diethylamino)- alpha, alpha -bis 4-(diethylamino)phenyl - was estimated using OECD QSAR toolbox v3.4

Benzenemethanol, 4-(diethylamino)- alpha, alpha -bis 4-(diethylamino)phenyl - was estimated to be not irritating to rabbit eyes.

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed (not irritating)

Respiratory irritation

Endpoint conclusion

Endpoint conclusion:

no study available

Additional information

Skin Irritation:

The skin irritation potential for Benzenemethanol, 4-(diethylamino)-alpha,alpha-bis(4-(diethylamino)phenyl)- (CAS No: 596-49-6)is estimated using OECD QSAR toolbox version 3.4 The test substance Benzenemethanol, 4-(diethylamino)-alpha,alpha-bis(4-(diethylamino)phenyl)- (CAS No: 596-49-6)is estimated to be not irritating to skin of New Zealand White rabbits.

Based on the QSAR prediction done using the Danish (Q)SAR Database, the skin irritation was estimated to be non-skin irritant on rabbits for Benzenemethanol, 4-(diethylamino)-alpha,alpha-bis(4-(diethylamino)phenyl)- (CAS No: 596-49-6). Thus it can be concluded that the substance Benzenemethanol, 4-(diethylamino)-alpha,alpha-bis(4-(diethylamino)phenyl)- (CAS No: 596-49-6) has negative skin irritation effects.

A skin irritation study was conducted ((Scientific Committee on Cosmetology (seventh series), 1988))in rabbits to observe the irritation potential of the similar substance 129-17-9. 0. 5 ml of a saturated solution of the test chemical in saline was applied to rabbit skin (site not specified) and effects were observed (duration not specified). Hence Patent Blue V (CAS No: 129-17-9) was considered to be not irritating to rabbit skin.

 

The skin irritation test was conducted (SIDS Initial Assessment Report for SIAM 10 N-Isopropyl-N’-phenyl-p-phenylenediamine (IPPD)-OECD SIDS- Tokyo, 15-17 March 2000) on 6 rabbits to assess the irritation potential of the similar substance 101-72-4. In the study, 500 mg of IPPD was applied as a fine powder to the pre-moistened skin of 6 rabbits for 24 hours The animals were maintained for 7days and the scores for erythema and edema recorded at 4, 24, 48, 72 and 168 hours after removal of the dressing.

 The scores were zero at all time points for all animals indicating that the test chemical, 4-(Isopropylamino) diphenylamine (CAS No: 101-72-4) is not a skin irritant in this study.

Based on the available information for the target and its read across substances and applying the weight of evidence of approach, Benzenemethanol, 4-(diethylamino)-alpha,alpha-bis(4-(diethylamino)phenyl) was not irritating to skin.

Eye Irritation: 

The ocular irritation potential of Benzenemethanol, 4-(diethylamino)- alpha, alpha -bis 4-(diethylamino)phenyl - was estimated using OECD QSAR toolbox v3.4

Benzenemethanol, 4-(diethylamino)- alpha, alpha -bis 4-(diethylamino)phenyl - was estimated to be not irritating to rabbit eyes.

An eye irritation study was conducted ((Scientific Committee on Cosmetology (seventh series), 1988)) in rabbits to observe the irritation potential of the similar substance 129-17-9

0.25 ml of a saturated solution of the test chemical in saline was instilled into the eyes of rabbits and effects were observed (duration not specified). Patent Blue V (CAS: 129-17-9) was observed to be not irritating to rabbit eyes.

Study was conducted on similar substance 3844-45-9 by S.D. Gettings et al, 1992 to determine their ocular irritation potential.

Ocular irritation was determined according to a modification of the Draize test (Draize, 1959).FD&C Blue 1(CAS: 3844-45-9) was prepared daily as a 3% (w/v) suspension in aqueous vehicle containing 0.5% (w/v) hydroxypropyl methylcellulose and 0.25% (w/v) laureth -10 acetate.

FD&C Blue 1 (3% w/v in aqueous vehicle) was administered once daily, for a total of 21 days, to the conjunctival sac of the right eye of New Zealand White Rabbits (6 of each sex/ group) at a dose volume of 30µl. Control animals (6 of each sex) received 30/µl of the vehicle daily.Ocular irritation was determined according to a modification of the Draize test (Draize, 1959). Interpretation of observations and assignment of scores were consistent with those described by the Consumer Product Safety Commission (1972).All eyes were scored for ocular irritation pretest (8 days, 24 hr and immediately priorto the initial dose) and approximately 24 hr after each treatment, prior to the next instillation of test material; on days 1, 3, 7, 14 and 21, the eyes were also evaluated for irritation 1 hr after treatment. In addition, all readily observable ocular structures were evaluated for eye stain and particle embedment 24 hr after each treatment. All animals survived and were free of significant clinical signs of toxicity throughout the study. Ophthalmoscopic examinations revealed that all animals were free of abnormalities, all animals were free of significant signs of ocular irritation, staining and particle embedment. Thus it was considered that the test substance FD&C Blue 1 (Brilliant Blue FCF) was not irritating to eyes.

Based on the available data for the target as well as its read across chemicals and applying the weight of evidence approach, Benzenemethanol, 4-(diethylamino)- alpha, alpha -bis 4-(diethylamino)phenyl can be considered as not irritating to eyes.

Justification for selection of skin irritation / corrosion endpoint:

data is from OECD QSAR toolbox v3.4

Justification for selection of eye irritation endpoint:

Data is from OECD QSAR toolbox v3.4

Justification for classification or non-classification

Available studies on Benzenemethanol, 4-(diethylamino)- alpha, alpha -bis 4-(diethylamino)phenyl indicate that it is not likely to cause any irritation to eye and skin.

Hence, Benzenemethanol, 4-(diethylamino)- alpha, alpha -bis 4-(diethylamino)phenyl can be evaluated as “Non- Irritant” to eyes and skin.