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EC number: 202-262-3 | CAS number: 93-61-8
Table No. I
Summary of Clinical Signs of Toxicity and Mortality
Test System : Sprague Dawley Rat
Sex : Male
Total Number of
Period of signs in days
From - to
No clinical signs observed
1 - 5
Day 0 - Day 14
Sex : Female
6 - 10
Table No. II
Summary of Evaluation of Dermal Reaction
Sex : Male
Period of signs
No dermal reaction observed
Mean Body Weight and Percent Body Weight Gain (g)
(mg/kg body weight)
Body weight Day 0
Body weight Day 7
% body weight gain
Body weight Day 14
day 7- 14
day 0- 14
Summary of Gross Pathological Findings
Gross Pathological Findings
No abnormality detected
Sex : Female
TS = Terminal Sacrifice
The reported study was designed and conducted to determine the acute dermal toxicity profile of the given test chemical as per OECD Guideline 402 (Acute Dermal Toxicity) in Sprague Dawley rats.
The test item was applied to shorn skin of 5 male and 5 female animals at 2000 mg/kg body weight. Administration of the test item at 2000 mg/kg did not result in any skin reaction at the site of application during the study period of 14 days.
Administration of the test item did not result in any signs of toxicity and mortality during the study period of 14 days. Animals exhibited normal body weight gain through the study period of 14 days. Gross pathological examination did not reveal any abnormalities attributable to the treatment.
Hence, it was concluded that the LD50 value was considered to be >2000 mg/kg bw, when male and female Sprague Dawley rats were occlusively treated with the given test chemical by dermal application following 14 days of observation period according to OECD Guideline 402 (Acute Dermal Toxicity).
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