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Ecotoxicological information

Long-term toxicity to fish

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Reference
Endpoint:
adult fish: sub(lethal) effects
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method
Justification for type of information:
Data is from computational model developed by USEPA.
Qualifier:
according to
Guideline:
other: Modeling database
Principles of method if other than guideline:
Estimation of 28 days Chv value of test chemical by modelling Database - ECOSAR v.1.11. The ECOSAR Class Program is a computerized version of the ECOSAR analysis procedures as currently practiced by the Office of Pollution Prevention and Toxics (OPPT). It has been developed within the regulatory constraints of the Toxic Substances Control Act (TSCA). It is a pragmatic approach to SAR. The structure-activity relationships (SARs) presented in this program are used to predict the aquatic toxicity of ch
emicals based on their similarity of structure to chemicals for which the aquatic toxicity has been previously measured. Most SAR calculations in the ECOSAR Class Program are based upon the octanol/water partition coefficient (Kow). Various surfactant SAR calculations are based upon the average length of carbon chains or the number of ethoxylate units.
GLP compliance:
no
Analytical monitoring:
not required
Vehicle:
not specified
Test organisms (species):
other: Fish
Test type:
static
Water media type:
freshwater
Total exposure duration:
28 d
Remarks on exposure duration:
Estimated data
Reference substance (positive control):
not specified
Key result
Duration:
28 d
Dose descriptor:
NOEC
Effect conc.:
83.368 mg/L
Nominal / measured:
estimated
Conc. based on:
test mat.
Basis for effect:
not specified
Remarks on result:
other: Neutral Organics SAR (Baseline Toxicity)
Validity criteria fulfilled:
no
Conclusions:
The estimated NOEC values of test chemical for fish after 28 days is 83.368 mg/l.
Executive summary:

Based on the prediction done using theEPI Suite ECOSAR version 1.10, the long term toxicity on fish was predicted for test chemical. On the basis of effects observed in a static freshwater system, the effect concentration NOEC value for the test chemical is estimated to be 83.368 mg/l for Species for 28 days duration. Based on this value, it can be concluded that the test substance can be considered as toxic to fish at environmentally relevant concentrations and can be consider to be classified in "not classified" as per the CLP classification criteria.

Description of key information

Based on the prediction done using theEPI Suite ECOSAR version 1.10, the long term toxicity on fish was predicted for test chemical. On the basis of effects observed in a static freshwater system, the effect concentration NOEC value for the test chemical is estimated to be 83.368 mg/l for Species for 28 days duration. Based on this value, it can be concluded that the test substance can be considered as toxic to fish at environmentally relevant concentrations and can be consider to be classified in "not classified" as per the CLP classification criteria.

Key value for chemical safety assessment

EC10, LC10 or NOEC for freshwater fish:
83.368 mg/L

Additional information

Based on the prediction done using theEPI Suite ECOSAR version 1.10, the long term toxicity on fish was predicted for test chemical. On the basis of effects observed in a static freshwater system, the effect concentration NOEC value for the test chemical is estimated to be 83.368 mg/l for Species for 28 days duration. Based on this value, it can be concluded that the test substance can be considered as toxic to fish at environmentally relevant concentrations and can be consider to be classified in "not classified" as per the CLP classification criteria.