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EC number: 237-748-4 | CAS number: 13967-50-5
Following Mutation Experiment 1 treatments of all the test strains, evidence of toxicity, in the form of a complete killing of the test bacteria was observed at 15.81 μg/plate and above in strains TA98 and TA100 in the absence and presence of S-9 and at 158.1 μg/plate and above in strain TA102 in the absence and presence of S-9. In addition, a marked reduction in revertant numbers was observed at 5 μg/plate in strains TA98 and TA100 in the absence of S-9 and at 50 μg/plate in strain TA102 in the absence and presence of S-9.
Following Mutation Experiment 2 treatments of all the test strains, evidence of toxicity, ranging from a slight thinning of the background bacterial lawn and/or a marked reduction in revertant numbers to complete killing of the test bacteria, was observed at 2.5 μg/plate and above in strains TA98 and TA100 in the absence and presence of S-9 and at 10 or 40 μg/plate and above in strain TA102 in the absence and presence of S-9 respectively.
The objective of the study was to evaluate the potential mutagenic activity of Potassium dicyanoaurate by examining its ability to revert three histidine-requiring strains of Salmonella typhimurium in the absence and presence of a rat liver metabolising system (S-9).
Potassium dicyanoaurate was tested for mutation (and toxicity) using a plate incorporation treatment methodology, in the absence and presence of S-9. Appropriate negative (vehicle) and positive controls were included.
It was concluded that Potassium dicyanoaurate did not induce mutation in three histidine-requiring strains (TA98, TA100, and TA102) of Salmonella typhimurium when tested under the conditions of this study. These conditions included treatments up to toxic concentrations in the absence and in the presence of a rat liver metabolic activation system (S-9).
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