Registration Dossier

Administrative data

Description of key information

Acute oral toxicity study in rats by the procedure according to OECD401 guideline.
Acute dermal toxicity study in rats, limit dose procedure according to OECD402 guideline.

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LD50
29.2 mg/kg bw
Quality of whole database:
One GLP-compliant study is available, performed according to OECD guideline and produced quality and reliable data.

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Quality of whole database:
One GLP-compliant study is available, performed according to OECD and EU guidelines and produced quality and reliable data.

Additional information

The acute oral toxicity of potassium dicyanoaurate was tested in rats following OECD guideline 401 and EU method B.1. Rats were orally gavaged with a single dose of potassium dicyanoaurate solution in desalted water at nominal concentrations of 10.0, 21.5 and 46.4 mg/kg, followed by a 14-day observation period. The LD50 was calculated to be 24.4 mg/kg bw for females and 36.1 mg/kg bw for males, giving an overall LD50 of 29.2 mg/kg bw. Signs of clinical toxicity were observed at 21.5 mg/kg bodyweight and higher (Berthold 1992).

In a limit test for acute dermal toxicity following OECD guideline 402 and EU method B.3, a single application of 2000 mg/kg bw potassium dicyanoaurate solution was applied occlusive on rats for 24 hours. No premature deaths or signs of toxicity were observed (Leuschner 2014). Potassium dicyanoaurate is not classified for acute dermal toxicity according to GHS and EC regulation 1272/2008.


Justification for selection of acute toxicity – oral endpoint
Only one study covering the endpoint but it is a Guideline study (OECD401) conducted to GLP standards.

Justification for selection of acute toxicity – dermal endpoint
Only one study covering the endpoint but it is a Guideline study (OECD402) conducted to GLP standards. No acute dermal toxicity or signs of clinical toxicity were observed at the limit dose of 2000 mg/kg bw silver cyanide.

Justification for classification or non-classification

According to GHS and EC regulation 1272/2008, potassium dicyanoaurate is classified as category 2 for acute oral toxicity based on a LD50 of 29.2 mg/kg bw. No classification for acute dermal toxicity is required as no toxicity effects were observed in a limit test at 2000 mg/kg bw.