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EC number: 237-748-4 | CAS number: 13967-50-5
Table 1. Local skin irritation - Preliminary Screening Test
Concentration (% w/w) in dimetyhl formamide
Local skin irritation
Table 2. Measurement of Ear Thickness and Mean Ear Thickness Changes - Preliminary Screening Test
Concentration (% w/w) in dimethyl formamide
Ear thickness measurement (mm)
Overall mean (mm)
Overall mean ear thickness change (%)
+ - ear thickness increase possibly due to residual test item on the ears.
- - no data, animal dead
Table 3. Disintegration per Minute, Disintegration per Minute/Node and Stimulation Index
A study was performed to assess the skin sensitization potential of potassium dicyanoaurate in the CBA/Ca strain mouse following topical application to the dorsal surface of the ear. The study was conducted according to the OECD Guideline 429 ('Skin sensitization: Local Lymph Node Assay') and EC method B42. The test was carried out according to GLP.
Materials and Methods
Following a preliminary test, the main test was conducted with groups of 4 mice treated with the test item at concentrations of 1, 2.5 and 5 % w/w in dimethyl formamide. The mice were treated by daily application of 25 µL of the test item to the dorsal surface of each ear for three consecutive days. A further group of four mice received the vehicle alone. Five days after the first topical application all mice were injected with PBS containing 3H -methyl thymidine.
The radioactive disintegration per minute were 6695.68, 53399.16, 57665.65 and 66160.86 dpm for vehicle control, 1, 2.5 and 5 % w/w, respectively. The Stimulation Index expressed as the mean radioactive incorporation for each treatment group divided by the mean radioactive incorporation of the vehicle control were 7.98, 8.61 and 9.88 for 1, 2.5 and 5 % w/w, respectively. The test item, potassium dicyanoaurate, was considered to be a sensitizer under the conditions of the test.
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