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EC number: 259-105-7 | CAS number: 54326-11-3
Table 1 Individual Clinical Observations and Mortality Data
Animal Number and Sex
Effects Noted After Initiation of Exposure (Hours)
Effects Noted After Initiation of Exposure (Days)
0 = No signs of systemic toxicity
See Overall remarks for Dermal Reactions Tables 2 and 3.
Table 4 Individual Bodyweights and Weekly Bodyweight Changes
Dose Level mg/kg
Bodyweight (g) at Day
Bodyweight Change (g) During Week
Table 5 Individual Necropsy Findings
Animal Numberand Sex
Time of Death
Killed Day 14
No abnormalities detected
The study was performed to assess the acute oral toxicity of the test material in the Wistar strain rat.The acute oral toxicity of the test item to the Wistar strain rat was assessed in a GLP-compliant study following OECD guideline 402 (adopted 1987) and Method B3 Acute Toxicity (Dermal) of Commission Regulation (EC) No. 440/2008 in a proprietary, experimental study (Harlan 2013). The study is considered reliable and relevant for use for this endpoint.
Method. A group of ten animals (five males and five females) was given a single, 24 hour, semi occluded dermal application of the test material to intact skin at a dose level of 2000 mg/kg bodyweight. Clinical signs and bodyweight development were monitored during the study. All animals were subjected to gross necropsy.
Mortality. There were no deaths.
Clinical Observations. There were no signs of systemic toxicity.
Dermal Irritation. Very slight erythema was noted at the test site of three females up to two days after dosing. There were no signs of dermal irritation noted at the test sites of the remaining animals.
Bodyweight. Animals showed expected gains in bodyweight over the study period, except for three animals which showed bodyweight loss during the first week but expected gain in bodyweight during the second week.
Necropsy. No abnormalities were noted at necropsy.
Conclusion. The acute dermal median lethal dose (LD50) of aluminum, benzoate C16-18-fatty acids complexess in the Wistar strain rat was found to be greater than 2000 mg/kg bodyweight.
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