2,2'-butyliminodiethanol

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

1977

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1977

Report date:

1977

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Version / remarks:

(adopted on 1981, 12th May; inhalation hazard test)

Deviations:

yes

Remarks:

(animals were observed for only 7 days, no details on animal husbandry, exposure period of up to 8 hours, concentration of test substance in air mixture was not verified analytically)

GLP compliance:

no

Test type:

other: Inhalation hazard test (IHT)

Test material

Test material information

Constituent 1

Reference substance name:

Butylethanolamine

IUPAC Name:

Butylethanolamine

Constituent 2

Reference substance name:

2-butylaminoethanol

EC Number:

203-904-5

EC Name:

2-butylaminoethanol

Cas Number:

111-75-1

Molecular formula:

C6H15NO

IUPAC Name:

2-(butylamino)ethanol

Details on test material:

- Name of test material (as cited in study report): Butylaethanolamin

Test animals

Species:

rat

Strain:

not specified

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Weight at study initiation: 230 g (mean)

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

not specified

Vehicle:

air

Details on inhalation exposure:

The test demonstrates the toxicity of an atmosphere saturated with vapours of the volatile components of a test substance at the temperature chosen for vapour generation (20 °C). 3 rats per sex were exposed sequentially to the vapours, generated by bubbling 200 l/h air through a substance column of about 5 cm above a fritted glassdisc in a glass cylinder for 8 h.

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

8 h

Concentrations:

24.69 mg/L

No. of animals per sex per dose:

3

Control animals:

no

Details on study design:

- Duration of observation period following administration: 7 days
- Frequency of observations: daily
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

other: Inhalation Hazard Test

Based on:

test mat.

Exp. duration:

8 h

Remarks on result:

other: no mortality was observed

Mortality:

No mortality was observed.

Clinical signs:

other: Mucous membrane irritation was observed.

Body weight:

The animals gained weight (250 g was the mean weight at the end of the study).

Gross pathology:

No abnormalities were observed.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Remarks:

Criteria used for interpretation of results: EU

Conclusions:

No LC50 could be established. No animals died.

Executive summary:

In an inhalation hazard test (IHT; BASF, 1977) 3 rats per sex were exposed to a saturated vapour atmosphere of the test substance for 8 hours. The mean nominal concentration of the test substance was 24.69 mg/L. No animal died. Mucous membrane irritation was observed and no abnormalities were seen at necropsy.