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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The conduct of the inhalation hazard test was similar to the IHT as reported in Annexe V of the OECD TG 403 (1981).

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1967
Report Date:
1967

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Version / remarks:
(adopted on 1981, 12th May; inhalation hazard test)
Deviations:
yes
Remarks:
(BASF test, animals were observed for only 7 days, no details only animal husbandry, exposure period of up to 8 hours, concentration of test substance in air mixture was not verified analytically)
GLP compliance:
no
Test type:
other: inhalation hazard test (IHT)

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Dibutylaethanolamin
- Analytical purity: >99%

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female
Details on test animals and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 225 g (mean)
No further data.

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
not specified
Vehicle:
not specified
Details on inhalation exposure:
BASF Test:
The test demonstrates the toxicity of an atmosphere saturated with vapours of the test substance at the temperature chosen for vapour generation (20°C). 6 rats per sex were exposed consecutively to the vapours, generated by bubbling 200 L/h air through a substance column of about 5 cm above a fritted glass disc in a glass cylinder for 8 h.
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
8 h
Concentrations:
0.15 mg/L
No. of animals per sex per dose:
6
Control animals:
no
Details on study design:
- Duration of observation period following administration: 7 days
- Frequency of observations: daily
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
other: Inhalation Hazard Test
Effect level:
0.15 mg/L air
Based on:
test mat.
Exp. duration:
8 h
Remarks on result:
other: No death occurred.
Mortality:
No death occurred.
Clinical signs:
other: None.
Body weight:
No data on body weight gain.
Gross pathology:
No abnormalities were observed.

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: expert judgment
Conclusions:
No mortalities was observed.