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EC number: 203-055-0 | CAS number: 102-79-4
Short-term toxicity to fish
The acute toxicity of Butyldiethanolamine towards Leucisdus idus was investigated according to German standard DIN 38412 in compliance with GLP (BASF, 1987). Test organisms were exposed to 0 (control), 100, 147, 215, 316, 464 and 464 (pH adjusted) mg/L of the test substance for 96 hours based on nominal test concentrations. The values were not analytically verified, but are assumed to be stable due to the low n-octanol/water partition coefficient (log Kow 0.58), the high water solubility (WS of 10,000 mg/L ), the moderate vapor pressure (VP 1.2 Pa at 25 °C) and the low Henry´s Law Constant (HLC 2.04 x E-5 Pa*m³/mol at 25 °C) of the chemical. One replicate with 10 animals for each test concentration and the control was prepared. As positive control, the reference substance chloroacetamide was used. As final result, LC 50 (96 h) values of > 316 - < 464 mg/L (no pH adjustment) and > 464 mg/L (pH adjusted) were determined. Validity criteria for the reference substance were fulfilled.
Short-term toxicity to aquatic invertebrates
A study (Ladwa, 2015) according to OECD Guideline 202 was conducted to determine the acute toxicity of the substance Butyldiethanolamine (CAS 102 -79 -4) towards Daphnia magna in compliance with GLP. Following a preliminary range-finding test and initial experiment, twenty daphnids (4 replicates of 5 animals) were exposed to an aqueous solution of the test item at concentrations of 10, 18, 32, 56 and 100 mg/L for 48 hours at a temperature of approximately 21 °C under static test conditions. The numbers of immobilized daphnia were recorded after 24 and 48 hours.
Analysis of the test preparations at 0 and 48 hours showed measured test concentrations to range from 106 % to 125 % of nominal concentration and so the results are based on nominal test concentrations. Exposure of Daphnia magna to the test item gave EC50 values of greater than 100 mg/L. The No Observed Effect Concentration was 100 mg/L. Results with the reference substance potassium dichromate were valid.
Long-term toxicity to aquatic invertebrates
There are no studies regarding long-term toxicity to aquatic invertebrates available for Butyldiethanolamine. Therefore, the data on its structural analogue Dibutylethanolamine (DBEA, CAS 102 -81 -8) is taken to evaluate this endpoint (please refer also to read-across statement attached in IUCLID Section 13).
The long-term toxicity towards Daphnia magna has been investigated according to OECD 211 for the read-across substance 2-dibutylaminoethanol (CAS 102-81-8; NITE, 2011). Test organisms were exposed to the test substance for 21 days resulting in a NOEC of 4.4 mg/L (based on reproduction) and an EC50 of 9 mg/L (based on reproduction).
Toxicity to aquatic algae and cyanobacteria
The toxicity of the substance BDEA (CAS 102 -79 -4) towards green algae (Pseudokirchneriella subcapitata) was determined according to OECD Guideline 201 in compliance with GLP (Vryenhoef, 2015).
Following a preliminary range-finding test, the test organisms were exposed to an aqueous solution of the test item at concentrations of 6.25, 12.5, 25, 50 and 100 mg/L (three replicate flasks per concentration) for 72 hours, under constant illumination and shaking at a temperature of 24 ± 1 °C. The test item formed an alkaline solution when dissolved in culture medium, particularly at the maximum concentration employed of 100 mg/L (pH 9.5). At the request of the Sponsor, in order to determine whether it was the alkaline nature of the test item which gave rise to the observed inhibition, an additional 100 mg/L test concentration was prepared whereby the pH was adjusted to 7.5 prior to inoculation with algae (three replicates). Samples of the algal populations were removed daily and cell concentrations determined for each control and treatment group, using a Coulter® Multisizer Particle Counter.
Analysis of the test preparations at 0 and 72 hours showed measured test concentrations to range from 92 % to 105 % of nominal and so the results are based on nominal test concentrations only. The biological data obtained confirmed that whilst the adjustment of the pH of the 100 mg/L test preparation did result in a decrease in the percentage inhibition observed, this decrease was not significant enough to attribute the effects seen in the non-pH adjusted preparations to the alkaline nature of the test item alone. Given that the alkalinity of the test preparations was considered to be due to an intrinsic property of the test item, and that inhibition of growth was also observed in a test preparation where the pH had been adjusted, it was considered appropriate to calculate the results based on the non-pH adjusted test preparations only. Exposure of Pseudokirchneriella subcapitata to the test item gave an ErC50 (72 h) value of > 100 mg/L, ErC10 (72 h) of 48 mg/L, a NOErC (72 h) of 25 mg/L, an EyC50 (72 h) of 57 and a NOEyC of 25 mg/L. The results from the positive control with potassium dichromate were within the normal ranges for this reference item.
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