Registration Dossier
Registration Dossier
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EC number: 209-170-2 | CAS number: 557-34-6
Immunotoxicity
Administrative data
Description of key information
Immunotoxicity: Supporting information: The LOAEL was 136 mg/kg bw/day for male and female mice (increases in direct plaque-forming activity of spleen cells and in lymphyocyte proliferation in response to mitogen stimulation).
Key value for chemical safety assessment
Effect on immunotoxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LOAEL
- 136 mg/kg bw/day
Additional information
Supporting information: Experimental results:
A model of BALB/c mice received Zinc acetate in drinking water concentrations of 500 and 1000 mg/L during the periods of gestation, lactation and postweaning. In mice exposed in utero to 136 mg zinc/kg bw/day, with exposure continuing postnatally, there were increases in direct plaque-forming activity of spleen cells and in lymphocyte proliferation in response to mitogen stimulation.
The LOAEL was 136 mg/kg bw/day for male and female mice (increases in direct plaque-forming activity of spleen cells and in lymphyocyte proliferation in response to mitogen stimulation).
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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