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In EFSA Journal (2008) 792,1-63 some generic considerations regarding the metabolism of methylquinoline are reported: methylquinoline are expected to be metabolised by hydroxylation of the ring structure in both rings, some diol metabolites may be formed through epoxide intermediates, hydroxylation of the alkyl groups is expected to be another main metabolic pathway and the quinolines may be oxidised at the heteroatom leading to N-oxide metabolites.

Some specific information regarding the metabolism of 2 -methylquinoline is summarised in NTP,2002.

In fact, as reported in Summary report of Toxicological Literature for Methylquinolines, NTP,2002 with reference to Saeki et al.,Biol. Pharm. Bull. 19(4):541-546, 1996, when tested in vitro, 2-methylquinoline was metabolized to 2-methylquinoline-5,6­dihydro-5,6-diol.

Different pathway of metabolism for 2-methylquinoline are observed based on route of subministration. As reported in Summary report of Toxicological Literature for Methylquinolines, NTP,2002 with reference to Komiya, Nichidai Igaku Zasshi 24(7):649-663, 1965. Abstract from CAPLUS 1967:63977 when 2-methylquinoline was injected subcutaneously in rabbit 3-hydroxyquinaldine, 6-hydroxyquinaldine, quinaldic acid and several unknown compounds were excreted in the urine but when given orally 2-methylquinoline was excreted unchanged.