Registration Dossier

Administrative data

Description of key information

2-methylquinoline is of certain concern regarding acute toxicity. 
The oral LD50 rats is 1230 mg/kg/bw.
The dermal LD50 rabbit is 1870 µL/kg equivalent to 1980 mg/kg.
No data are available regarding acute toxicity of 2-methylquinoline for inhalation route.

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LD50
Value:
1 230 mg/kg bw
Quality of whole database:
Data from Summary report of Toxicological Literature for Methylquinolines, NTP,2002

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LD50
Value:
1 980 mg/kg bw
Quality of whole database:
Data from Summary report of Toxicological Literature for Methylquinolines, NTP,2002

Additional information

2-methylquinoline is of certain concern regarding acute toxicity. The oral LD50 rats is 1230 mg/kg/bw. The dermal LD50 rabbit is 1870 µL/kg equivalent to 1980 mg/kg. No data are available regarding acute toxicity for inhalation route.

Oral exposure:

As reported in Summary report of Toxicological Literature for Methylquinolines, NTP,2002 with reference to AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 4, Pg. 119, 1951 when 2-methylquinoline was administered orally to rats, the LD50 was 1230 mg/kg.

Inhalation exposure:

No data available.

Dermal exposure:

As reported in Summary report of Toxicological Literature for Methylquinolines, NTP,2002 with reference to AMA Archives of Industrial Hygiene and Occupational Medicine.Vol. 4, Pg. 119, 1951 when 2-methylquinoline was applied to the skin of the rabbit, the LD50 was 1870 µL/kg equivalent to 1980 mg/kg.

Justification for classification or non-classification

Based on LD50 oral rat= 1230 mg/kg/bw and LD50 dermal rabbit= 1980 mg/kg/bw 2-methylquinoline is classified H302 (acute oral toxicity cat.4) and H312 (acute dermal toxicity cat.4) according to CLP Regulation (EC n.1272/2008).