Registration Dossier

Administrative data

Description of key information

The substance show signs of skin and eye irritation in test on animals.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Skin irritation/corrosion:

As reported in Summary report of Toxicological Literature for Methylquinolines, NTP,2002 with reference to Marhold et all, Prehled Prumyslove Toxikologie; Organicke Latky. Avicenum, Prague, Czechoslovakia, 1986 when 2-methylquinoline was tested on rabbit skin at 500 mg for 24 hours mild irritation was observed. To confirm this effect in Summary report of Toxicological Literature for Methylquinolines, NTP,2002 is reported also a study on coal tar, which contains 0.6% to 4.2% of 2-methylquinoline: coal tar caused thickness in guinea-pig epidermis (Sarkany and Gaylarde, Clin. Exp. Dermatol. 1/1:51-58, 1976)  

Eye irritation/corrosion:

As reported in Summary report of Toxicological Literature for Methylquinolines, NTP,2002 2 -methylquinoline caused severe eye irritation in rabbits at a dose of 750 μg. The reference mentioned by NTP, 2002 in not found using the link indicated but a report of BCOP test on different compounds is published on NTP website (see http://ntp.niehs.nih.gov/iccvam/docs/ocutox_docs/ocubrd/bcop/bcop7.pdf, document BCOP BRD: Section 7-March2006). In this document the results of Intralaboratory CV Analysis of BCOP performed in 1998 for different compounds were reported: for 2-methylquinoline the BCOP test gave a IVIS = 25.5 with an in vitro prediction of moderate eye irritation.

According to OECD 437, with 3 <IVIS≤ 55 no prediction should be done regarding eye irritation. Based on precautionary principle(IVIS is not less than 3 and so it is not possible exclude skin irritation) and considering that eyes generally are more sensitive than skin and from experimental study the substance is skin irritant, 2-methylquinoline should be considered reasonably eye irritant.


Justification for selection of skin irritation / corrosion endpoint:
Data from Summary report of Toxicological Literature for Methylquinolines, NTP,2002

Justification for selection of eye irritation endpoint:
Data from Summary report of Toxicological Literature for Methylquinolines, NTP,2002

Effects on skin irritation/corrosion: moderately irritating

Effects on eye irritation: irritating

Justification for classification or non-classification

Based on the results from experimental studies (mild irritation after application of the substance on rabbit skin and IVIS of BCOP test = 25,5) and considering that eyes generally are more sensitive than skin the classification proposed for the substance is irritant for skin (H315: skin irritation/corrosion cat.2) and irritant for eye (H319: Eye damage/eye irritation cat.2) according to CLP Regulation (EC n.1272/2008).