Cetylpyridinium chloride

Other distribution data

Administrative data

Endpoint:

other distribution data

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

27 May 2008 to 24 June 2008

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: The report was a custom-made study based on the simulation system described in an established guideline, including methods that were well-documented and scientifically acceptable, and conducted in compliance with GLP requirements.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2008

Report date:

2008

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

other: operating system as described in OECD Guideline 303A

Deviations:

not applicable

Principles of method if other than guideline:

The study was a custom-made study that determined the removal of the substance from the aqueous phase of a simulated activated sludge unit over the course of seven days. The operating system (simulated activated sludge unit) was set up as decribed in OECD Guideline 303A. The removal rate of the substance was determined by direct measurement of concentrations in water over time.

GLP compliance:

yes

Type of study:

other: Distribution between aqueous phase and sludge in a simulated activated sludge unit

Media:

water - sewage sludge

Test material

Test material information

Constituent 1

Reference substance name:

Cetylpyridinium chloride

EC Number:

204-593-9

EC Name:

Cetylpyridinium chloride

Cas Number:

123-03-5

Molecular formula:

C21H38N.Cl

IUPAC Name:

cetylpyridinium chloride

Constituent 2

Reference substance name:

CPC

IUPAC Name:

CPC

Test material form:

solid: particulate/powder

Remarks:

migrated information: powder

Details on test material:

The substance identifiers listed above describe the anhydrous form, although the substance hydrates under ambient conditions and also exists in the monohydrate form (CPC monohydrate; CAS No. 6004-24-6). The test substance was in the form of a white to off-white powder.

Results and discussion

Any other information on results incl. tables

Percentage removal Cetylpyridinium Chloride (monohydrate) from the unit with sludge

Day	Water Sample	Analysed (mg/l)	LOD	% Removal^2CPC
0	Influent	0.200
	Effluent^1	<LOD	0.0254	≥87
1	Influent	0.494
	Effluent	<LOD	0.0254	≥95
2	Influent	0.524
	Effluent	<LOD	0.0254	≥95
3	Influent	0.120
	Effluent	<LOD	0.0254	≥79
4	Influent	0.660
	Effluent	<LOD	0.0254	≥96
5	Influent	0.385
	Effluent	<LOD	0.0254	≥93
6	Influent	0.359
	Effluent	<LOD	0.0254	≥93

1 Effluent is taken one day after the influent.

2 Calculated as (Conc. Influent-Conc. Effluent) * Conc. Effluent * 100%

LOD: limit of detection

Percentage removal Cetylpyridinium Chloride (monohydrate) from the unit without sludge

Day	Water Sample	Analysed (mg/l)	% Removal^2CPC
0	Influent	0.394
	Effluent^1	0.0600	85
1	Influent	0.528
	Effluent	0.107	80
2	Influent	0.458
	Effluent	0.0900	80
3	Influent	0.137
	Effluent	0.121	12
4	Influent	0.586
	Effluent	0.124	79
5	Influent	0.501
	Effluent	0.119	76
6	Influent	0.427
	Effluent	0.0900	79

1 Effluent is taken one day after the influent.

2 Calculated as (Conc. Influent-Conc. Effluent) * Conc. Effluent * 100%

Applicant's summary and conclusion

Conclusions:

In the unit with sludge, CPC was removed from ≥79% to ≥96%. In the unit without sludge, CPC was removed 76% to 85% indicating that the sludge caused an additional removal of at least 20%. Therefore, cetylpyridinium chloride (monohydrate) was removed almost completely from the test system by adsorption to laboratory equipment and sludge.