Registration Dossier

Administrative data

Endpoint:
other distribution data
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
27 May 2008 to 24 June 2008
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The report was a custom-made study based on the simulation system described in an established guideline, including methods that were well-documented and scientifically acceptable, and conducted in compliance with GLP requirements.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2008
Report Date:
2008

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
other: operating system as described in OECD Guideline 303A
Deviations:
not applicable
Principles of method if other than guideline:
The study was a custom-made study that determined the removal of the substance from the aqueous phase of a simulated activated sludge unit over the course of seven days. The operating system (simulated activated sludge unit) was set up as decribed in OECD Guideline 303A. The removal rate of the substance was determined by direct measurement of concentrations in water over time.
GLP compliance:
yes
Type of study:
other: Distribution between aqueous phase and sludge in a simulated activated sludge unit
Media:
water - sewage sludge

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder
Details on test material:
The substance identifiers listed above describe the anhydrous form, although the substance hydrates under ambient conditions and also exists in the monohydrate form (CPC monohydrate; CAS No. 6004-24-6). The test substance was in the form of a white to off-white powder.

Results and discussion

Any other information on results incl. tables

Percentage removal Cetylpyridinium Chloride (monohydrate) from the unit with sludge

Day

Water Sample

Analysed (mg/l)

LOD

% Removal2CPC

0

Influent

0.200

 

 

Effluent1

<LOD

0.0254

≥87

1

Influent

0.494

 

 

Effluent

<LOD

0.0254

≥95

2

Influent

0.524

 

 

Effluent

<LOD

0.0254

≥95

3

Influent

0.120

 

 

Effluent

<LOD

0.0254

≥79

4

Influent

0.660

 

 

Effluent

<LOD

0.0254

≥96

5

Influent

0.385

 

 

Effluent

<LOD

0.0254

≥93

6

Influent

0.359

 

 

Effluent

<LOD

0.0254

≥93

1 Effluent is taken one day after the influent.

2 Calculated as (Conc. Influent-Conc. Effluent) * Conc. Effluent * 100%

LOD: limit of detection

Percentage removal Cetylpyridinium Chloride (monohydrate) from the unit without sludge

Day

Water Sample

Analysed (mg/l)

% Removal2CPC

0

Influent

0.394

 

Effluent1

0.0600

85

1

Influent

0.528

 

Effluent

0.107

80

2

Influent

0.458

 

Effluent

0.0900

80

3

Influent

0.137

 

Effluent

0.121

12

4

Influent

0.586

 

Effluent

0.124

79

5

Influent

0.501

 

Effluent

0.119

76

6

Influent

0.427

 

Effluent

0.0900

79

1 Effluent is taken one day after the influent.

2 Calculated as (Conc. Influent-Conc. Effluent) * Conc. Effluent * 100%

Applicant's summary and conclusion

Conclusions:
In the unit with sludge, CPC was removed from ≥79% to ≥96%. In the unit without sludge, CPC was removed 76% to 85% indicating that the sludge caused an additional removal of at least 20%. Therefore, cetylpyridinium chloride (monohydrate) was removed almost completely from the test system by adsorption to laboratory equipment and sludge.